Department of Physical Education, Chungnam National University, Daehak-ro, Yuseong-gu, Daejeon 34134, South Korea.
Research Institute of Sports and Industry Science, Hanseo University, #1 Hanseo-ro, Haemi-myeon, Seosan, 31962, South Korea.
Arch Gerontol Geriatr. 2024 Feb;117:105273. doi: 10.1016/j.archger.2023.105273. Epub 2023 Nov 12.
This study investigated the association among thigh volume features, interleukin (IL)-6, and immunocytes in the context of the older people with sarcopenia.
This study comprised a cohort of 437 older males diagnosed with sarcopenia, and their average age of 70.41 ± 4.86 years. This study involved conducting correlation and multiple linear regression analyses to investigate the connections between thigh volume, IL-6, and immunocytes.
Total thigh volume (TTV) showed positive connections with thigh muscle volume (TMV), natural killer (NK) cells, and CD8 + T cells. TMV had negative associations with thigh fat volume (TFV) and IL6 but displayed positive connections with other factors. IL-6 had adverse associations with all the other variables except for TFV. NK cells showed significant positive relations with all adaptive immune cells, though showing not TFV and IL-6. The CD3+ T cells, CD4+ T cells, CD8+ T cells, and CD19+ B cells exhibited positive correlations with each other including NK cells, though showing not TFV and IL-6. In the regression analysis, TMV exhibited significant positive effects on NK cells (β = 0.304), CD3+ T cells (β = 0.182), CD4+ T cells (β = 0.109), CD8+ T cells (β = 0.226), and CD19+ B cells (β = 0.197). On the other hand, IL-6 had significant negative effects on NK cells (β = -0.292), CD3+ T cells (β = -0.352), CD4+ T cells (β = -0.184), CD8+ T cells (β = -0.387), and CD19+ B cells (β = -0.366).
This study found that there existed a direct association among thigh muscle with sarcopenia, myokine, and immunocytes.
The aging process involves the immune system playing a vital role in sarcopenia development, and it is thought that myokines released by skeletal myocytes. However, the exact relationship between TMV, myokines, and immunocytes in older male adults affected by sarcopenia remains unclear. This study found that myokines observed in sarcopenia showed a negative correlation with immunocytes, while muscle mass had a positive correlation with immunocytes. In the meantime, this research delved into the use of a regression model to examine how TMV and myokines individually contribute to explaining the presence of innate and adaptive immunocytes in older individuals with sarcopenia.
本研究调查了在患有肌肉减少症的老年人中，大腿体积特征、白细胞介素 (IL)-6 和免疫细胞之间的关联。
本研究包括一组 437 名被诊断患有肌肉减少症的老年男性，他们的平均年龄为 70.41±4.86 岁。本研究进行了相关性和多元线性回归分析，以调查大腿体积、IL-6 和免疫细胞之间的关系。
总大腿体积 (TTV) 与大腿肌肉体积 (TMV)、自然杀伤 (NK) 细胞和 CD8+T 细胞呈正相关。TMV 与大腿脂肪体积 (TFV) 和 IL6 呈负相关，但与其他因素呈正相关。IL-6 与所有其他变量均呈负相关，除了 TFV。NK 细胞与所有适应性免疫细胞均呈显著正相关，尽管与 TFV 和 IL-6 无关。CD3+T 细胞、CD4+T 细胞、CD8+T 细胞和 CD19+B 细胞彼此之间呈正相关，包括 NK 细胞，但与 TFV 和 IL-6 无关。在回归分析中，TMV 对 NK 细胞 (β=0.304)、CD3+T 细胞 (β=0.182)、CD4+T 细胞 (β=0.109)、CD8+T 细胞 (β=0.226) 和 CD19+B 细胞 (β=0.197) 均有显著的正效应。另一方面，IL-6 对 NK 细胞 (β=-0.292)、CD3+T 细胞 (β=-0.352)、CD4+T 细胞 (β=-0.184)、CD8+T 细胞 (β=-0.387) 和 CD19+B 细胞 (β=-0.366) 均有显著的负效应。
本研究发现，大腿肌肉与肌肉减少症、肌肉因子和免疫细胞之间存在直接关联。
衰老过程中免疫系统在肌肉减少症的发展中起着至关重要的作用，人们认为骨骼肌细胞释放的肌肉因子与此有关。然而，肌肉减少症老年人中 TMV、肌肉因子和免疫细胞之间的确切关系尚不清楚。本研究发现，肌肉减少症中观察到的肌肉因子与免疫细胞呈负相关，而肌肉质量与免疫细胞呈正相关。同时，本研究还探讨了使用回归模型来检查 TMV 和肌肉因子如何单独解释患有肌肉减少症的老年人中固有和适应性免疫细胞的存在。
