钠稳态和信号转导：星形胶质细胞功能的核心和枢纽。

Sodium homeostasis and signalling: The core and the hub of astrocyte function.

机构信息

Institute of Neurobiology, Faculty of Mathematics and Natural Sciences, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany.

Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PT, United Kingdom; Achucarro Centre for Neuroscience, IKERBASQUE, Basque Foundation for Science, 48011 Bilbao, Spain; Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University, Shenyang, China; International Collaborative Center on Big Science Plan for Purinergic Signaling, Chengdu University of Traditional Chinese Medicine, Chengdu, China; Department of Stem Cell Biology, State Research Institute Centre for Innovative Medicine, LT-01102, Vilnius, Lithuania.

出版信息

Cell Calcium. 2024 Jan;117:102817. doi: 10.1016/j.ceca.2023.102817. Epub 2023 Nov 4.

DOI:10.1016/j.ceca.2023.102817

PMID:37979342

Abstract

Neuronal activity and neurochemical stimulation trigger spatio-temporal changes in the cytoplasmic concentration of Na ions in astrocytes. These changes constitute the substrate for Na signalling and are fundamental for astrocytic excitability. Astrocytic Na signals are generated by Na influx through neurotransmitter transporters, with primary contribution of glutamate transporters, and through cationic channels; whereas recovery from Na transients is mediated mainly by the plasmalemmal Na/K ATPase. Astrocytic Na signals regulate the activity of plasmalemmal transporters critical for homeostatic function of astrocytes, thus providing real-time coordination between neuronal activity and astrocytic support.

摘要

神经元活动和神经化学刺激引发星形胶质细胞质内钠离子浓度的时空变化。这些变化构成了钠离子信号的基础，对星形胶质细胞的兴奋性至关重要。星形胶质细胞的钠离子信号是由神经递质转运体通过钠离子内流产生的，其中谷氨酸转运体的贡献最大，同时也通过阳离子通道产生；而钠离子瞬变的恢复主要由质膜上的 Na+/K+ATP 酶介导。星形胶质细胞的钠离子信号调节质膜转运体的活性，这对星形胶质细胞的稳态功能至关重要，从而为神经元活动和星形胶质细胞支持之间提供实时协调。