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抑制 UFM1 表达可抑制癌症进展，并与口腔鳞状细胞癌的不良预后和免疫浸润有关。

Inhibition of UFM1 expression suppresses cancer progression and is linked to the dismal prognosis and immune infiltration in oral squamous cell carcinoma.

机构信息

Department of Radiology, Affiliated Hospital of Zunyi Medical University, Zunyi, China.

Department of Stomatology, Affiliated Hospital of Zunyi Medical University, Zunyi, China.

出版信息

Aging (Albany NY). 2023 Nov 17;15(22):13059-13076. doi: 10.18632/aging.205219.

DOI:10.18632/aging.205219
PMID:37980168
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10713408/
Abstract

BACKGROUND

Ubiquitin fold modifier 1 (UFM1) overexpression is associated with cancer cell proliferation, migration and invasion. However, the roles and pathways of UFM1 in oral squamous cell carcinoma (OSCC) has remained undefined.

METHODS

The expression of UFM1 and the relationship between UFM1 expression and prognosis were investigated using data of OSCC patients from The Cancer Genome Atlas (TCGA) database. The UFM1 co-expressed genes, and the association between the UFM1 expression and immune cells and ubiquitination were explored. The effects of UFM1 expression on the growth and migration of OSCC cells were investigated by siRNA interference, Cell Counting Kit-8 (CCK-8), Transwell, Western blotting, and wound healing experiments.

RESULTS

UFM1 was highly expressed in OSCC. UFM1 overexpression was associated with short overall survival, disease-specific survival, and progression-free interval, and was an adverse factor for prognosis in OSCC. UFM1-related nomograms were significantly associated with poor prognosis in OSCC patients. Decreased UFM1 expression could inhibit the proliferation, migration, and invasion of OSCC cells. UFM1 was associated with the immune cells (such as the Th17 cells, T helper cells, and cytotoxic cells) and ubiquitination.

CONCLUSION

Elevated UFM1 expression was associated with poor prognosis, ubiquitination and immune infiltration in OSCC, and inhibition of UFM1 expression delayed OSCC progression, showing that UFM1 could be a biomarker for prognosis and treating OSCC patients.

摘要

背景

泛素样修饰因子 1（UFM1）过表达与癌细胞增殖、迁移和侵袭有关。然而，UFM1 在口腔鳞状细胞癌（OSCC）中的作用和途径仍未确定。

方法

利用癌症基因组图谱（TCGA）数据库中 OSCC 患者的数据，研究 UFM1 的表达情况以及 UFM1 表达与预后之间的关系。探索 UFM1 的共表达基因，以及 UFM1 表达与免疫细胞和泛素化之间的关系。通过 siRNA 干扰、细胞计数试剂盒-8（CCK-8）、Transwell、Western blot 和划痕愈合实验，研究 UFM1 表达对 OSCC 细胞生长和迁移的影响。

结果

UFM1 在 OSCC 中高表达。UFM1 过表达与总生存期、疾病特异性生存期和无进展间隔短有关，是 OSCC 预后不良的因素。UFM1 相关列线图与 OSCC 患者的不良预后显著相关。降低 UFM1 表达可抑制 OSCC 细胞的增殖、迁移和侵袭。UFM1 与免疫细胞（如 Th17 细胞、辅助性 T 细胞和细胞毒性细胞）和泛素化有关。

结论

UFM1 表达升高与 OSCC 的不良预后、泛素化和免疫浸润有关，抑制 UFM1 表达可延缓 OSCC 进展，表明 UFM1 可作为 OSCC 患者预后和治疗的标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11cd/10713408/3adb2d5e1956/aging-15-205219-g012.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11cd/10713408/527918ceb702/aging-15-205219-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11cd/10713408/1d98c190bb5e/aging-15-205219-g009.jpg
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