Hakulinen T, Knekt P, Uotila O, Isomäki H
Scand J Rheumatol. 1986;15(3):285-9. doi: 10.3109/03009748609092594.
The survival rate for cancer patients with rheumatoid arthritis was compared with that for non-rheumatoid cancer patients. This was accomplished by linking two nationwide Finnish data registers, the Social Insurance Institution's Population Register and the Finnish Cancer Registry. For 2012 of the 2062 rheumatoid patients with cancer diagnosed after the diagnosis of rheumatoid arthritis, the Cancer Registry was successfully searched for a non-rheumatoid of diagnosis of control patient who matched with respect to sex, age, year of diagnosis of cancer and location of the tumour (and also, for leukaemia, with respect to cell type). The 5-year relative survival rate for male rheumatoid patients was 21.2% and, for the control cancer patients, 25.4%. In females, the corresponding rates were 38.2% for the rheumatoid patients and 41.2% for the control patients (p less than 0.05). At some sites, particularly with leukaemia, the rates for the rheumatoid patients were lower than those for the control patients. The difference, however, only reached a 5% significance level for colorectal cancer in males. Rheumatoid arthritis and its treatment do not seem to have any appreciable effect on the survival of cancer patients.
将类风湿性关节炎癌症患者的生存率与非类风湿性癌症患者的生存率进行了比较。这是通过链接芬兰两个全国性数据登记处来完成的,即社会保险机构的人口登记处和芬兰癌症登记处。对于2062名在诊断出类风湿性关节炎后被诊断出患有癌症的类风湿患者中的2012名,在癌症登记处成功找到了一名在性别、年龄、癌症诊断年份和肿瘤位置(对于白血病,还包括细胞类型)方面相匹配的非类风湿对照患者。男性类风湿患者的5年相对生存率为21.2%,对照癌症患者为25.4%。在女性中,类风湿患者的相应比率为38.2%,对照患者为41.2%(p小于0.05)。在某些部位,特别是白血病,类风湿患者的比率低于对照患者。然而,这种差异仅在男性结直肠癌中达到5%的显著水平。类风湿性关节炎及其治疗似乎对癌症患者的生存没有任何明显影响。