Naggar L, Jaeger P, Burckhardt P, Zwahlen A
Schweiz Med Wochenschr. 1986 Dec 13;116(50):1771-3.
Observation of a case of myelofibrosis with myeloid metaplasia of liver and spleen associated with hypocalcemia led us to investigate whether this association was fortuitous. We retrospectively analyzed the data of 30 patients with myelofibrosis and identified 9 patients with hypocalcemia out of 22 in whom the plasma calcium level corrected for serum protein could be obtained, i.e. a prevalence of hypocalcemia of 41%. The spleen was significantly larger in the patients with hypocalcemia than in those with normal plasma calcium level, suggesting that hypocalcemia was related to the duration of the disease. In 5 patients with hypocalcemia, biological and/or morphological evidence of osteomalacia was found. It is concluded that an association exists between myelofibrosis and hypocalcemia, possibly as a consequence of a disturbed vitamin D metabolism.
对一例伴有肝脾髓外化生的骨髓纤维化合并低钙血症患者的观察，促使我们研究这种关联是否为偶然。我们回顾性分析了30例骨髓纤维化患者的数据，在22例可获得校正血清蛋白后的血浆钙水平的患者中，识别出9例低钙血症患者，即低钙血症患病率为41%。低钙血症患者的脾脏明显大于血浆钙水平正常的患者，提示低钙血症与疾病持续时间有关。在5例低钙血症患者中，发现了骨软化症的生物学和/或形态学证据。结论是骨髓纤维化与低钙血症之间存在关联，可能是维生素D代谢紊乱的结果。
