University of Lodz, Faculty of Biology and Environmental Protection, Department of Molecular Biotechnology and Genetics, Banacha St. 12/16, 90-237 Lodz, Poland; University of Lodz, Doctoral School of Exact and Natural Sciences, Banacha Street 12/16, 90-237 Lodz, Poland.
University of Lodz, Faculty of Biology and Environmental Protection, Department of Molecular Biotechnology and Genetics, Banacha St. 12/16, 90-237 Lodz, Poland.
Biochim Biophys Acta Rev Cancer. 2023 Nov;1878(6):189024. doi: 10.1016/j.bbcan.2023.189024. Epub 2023 Nov 18.
For decades, common chemotherapeutic drugs have been established to trigger apoptosis, the preferred immunologically "silent" form of cell death. The primary objective of this review was to show that various FDA-approved chemotherapeutic drugs, including cisplatin, cyclosporine, doxorubicin, etoposide, 5-fluorouracil, gemcitabine, paclitaxel, or vinblastine can trigger necroptosis and pyroptosis. We aimed to provide the advantages and disadvantages of the induction of the given type of cell death by chemotherapeutical agents. Moreover, we give a short overview of the molecular mechanism of each type of cell death and indicate the existing crosstalks between cell death types. Finally, we provide a comparison of cell death types to facilitate the exploration of cell death types induced by other chemotherapeutical agents. Understanding the cell death pathway induced by a drug can lessen side effects and assist the discovery of new combinations with synergistic effects and low systemic toxicity.
几十年来，已确立常用的化疗药物来触发细胞凋亡，这是首选的免疫“沉默”形式的细胞死亡。本综述的主要目的是表明，各种已批准的 FDA 化疗药物，包括顺铂、环孢素、阿霉素、依托泊苷、5-氟尿嘧啶、吉西他滨、紫杉醇或长春碱，可触发细胞坏死和细胞焦亡。我们旨在提供化疗药物诱导给定类型细胞死亡的优缺点。此外，我们简要概述了每种类型细胞死亡的分子机制，并指出了细胞死亡类型之间的现有串扰。最后，我们比较了细胞死亡类型，以促进探索其他化疗药物诱导的细胞死亡类型。了解药物诱导的细胞死亡途径可以减少副作用，并有助于发现具有协同作用和低全身毒性的新组合。
