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慢性肾脏病的营养管理:儿童与成人的差异和特殊需求。

Nutrition Management for Chronic Kidney Disease: Differences and Special Needs for Children and Adults.

机构信息

Division of Pediatric Nephrology, Rady Children's Hospital, University of California, San Diego, CA.

Department of Pediatric Nephrology, St John's Medical College Hospital, Bangalore, India.

出版信息

Semin Nephrol. 2023 Jul;43(4):151441. doi: 10.1016/j.semnephrol.2023.151441. Epub 2023 Nov 18.

Abstract

Common goals of nutritional therapy across the spectrum of pediatric and adult chronic kidney disease (CKD) include maintaining normal body mass and composition and reducing associated morbidity and mortality. Adult nephrologists caring for children and adolescents may be challenged by the existing complexities in identifying and interpreting the nutritional status and growth in children. Pediatric nephrologists may face situations that call for a sound knowledge of assessing nutritional status and providing nutrition therapy for adolescents and young adults. One important additional nutrition goal in children is to achieve normal growth and development. Children are growing and therefore need more calories and nutrients than just maintaining their body weight and composition. Lack of weight and height gain actually is considered failure to thrive in children. Some fundamental differences in approaches to nutritional therapy in CKD are necessitated based on the etiology of CKD. A large proportion of adults with CKD are diabetics, so the approach would be a low-carbohydrate diet. Children with CKD, especially young ones, often are anorexic, so calorie supplements that could include quite a lot of carbohydrates often are prescribed. More adults with CKD have hypertension and atherosclerotic comorbidities, which result in recommendations for low-salt and low-fat diets. Children with CKD often have salt and electrolyte wasting disease states and would require normal- or even high-salt diets, and fats often are included in supplements to bolster calorie intake. Low-protein diets often are recommended in adults with predialysis CKD to slow disease progression. Children are growing and have a higher protein daily requirement. Low-protein diets have not been found to be efficacious in children with CKD, in achieving normal growth, or in slowing disease progression. Adult nephrologists caring for children and adolescents may be challenged by the existing complexities in identifying and interpreting nutritional status and growth in children. Pediatric nephrologists may face situations that call for a sound knowledge of assessing nutritional status and providing nutrition therapy for adolescents and young adults. This article discusses the differences in the assessment of nutritional status between children and adults, as well as provides a comprehensive approach to nutritional management for CKD across the age spectrum. Semin Nephrol 43:x-xx © 2023 Elsevier Inc. All rights reserved.

摘要

儿科和成人慢性肾脏病(CKD)营养治疗的共同目标包括维持正常的体重和组成,减少相关发病率和死亡率。治疗儿童的成人肾病学家可能会面临在识别和解释儿童营养状况和生长方面存在的复杂性。儿科肾病学家可能会面临需要对评估营养状况和为青少年和年轻人提供营养治疗有深入了解的情况。儿童的另一个重要营养目标是实现正常的生长和发育。儿童在成长,因此需要比维持体重和组成更多的卡路里和营养物质。体重和身高增长不足实际上被认为是儿童生长不良。基于 CKD 的病因,需要对 CKD 中的营养治疗方法进行一些基本的区别。很大一部分成人 CKD 患者是糖尿病患者,因此方法是低碳水化合物饮食。CKD 儿童,尤其是年幼的儿童,通常食欲不振,因此通常会开卡路里补充剂,其中可能包括很多碳水化合物。更多的成人 CKD 患者有高血压和动脉粥样硬化合并症,这导致推荐低盐和低脂饮食。CKD 儿童经常有盐和电解质丢失的疾病状态,需要正常甚至高盐饮食,并且经常在补充剂中添加脂肪以增加热量摄入。在接受透析前 CKD 的成人中,常推荐低蛋白饮食以减缓疾病进展。儿童在成长,每日需要更高的蛋白质。在 CKD 儿童中,低蛋白饮食并未被发现能有效实现正常生长或减缓疾病进展。治疗儿童的成人肾病学家可能会面临在识别和解释儿童营养状况和生长方面存在的复杂性。儿科肾病学家可能会面临需要对评估营养状况和为青少年和年轻人提供营养治疗有深入了解的情况。本文讨论了儿童和成人营养状况评估之间的差异,并提供了跨年龄范围的 CKD 营养管理综合方法。 Semin Nephrol 43:x-xx © 2023 Elsevier Inc. All rights reserved.

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