Synthesis, biological evaluation and studies of some new analogues of 3,5-vdisubstituted thiazolidin-2,4-dione.

A new series of 3,5-disubstituted thiazolidin-2,4-dione molecules were derived and characterized using various spectral techniques (H NMR, IR, carbon, hydrogen, nitrogen, etc.) and physicochemical parameters. The molecules were derived using Knoevenagel condensation followed by Mannich reaction and further synthesized analogues were screened for their antioxidant and antimicrobial potential using 2,2-diphenyl-1-picrylhydrazyl free radical scavenging method and serial tube dilution method, respectively, along with studies (docking and absorption, distribution, metabolism and excretion parameters) to explore the drug-receptor interaction and druglikeness. In antimicrobial screening, the analogs , , and displayed promising activity while molecule exhibited better antioxidant potential in the series. In molecular docking analysis, the best-fitted analogs, namely, and , showed good interactions.