Bratisl Lek Listy. 2023;124(12):892-895. doi: 10.4149/BLL_2023_141.
During cancer surgery, the perioperative period is characterized by stress response and immunosuppression that can lead to further worsening of the disease and metastatic spread. Local anesthetics have antiproliferative, cytotoxic and antimetastatic effects on cancer cells in vitro. There is scientific evidence that local anesthetics possess anti-inflammatory effects, help to preserve normal immune function and reduce the possibility of metastatic spread. Anesthetic care affects pain, inflammation, and immunosuppression, which may have a great impact on the outcome of oncological patients. The use of local anesthetics during the perioperative period in oncological patients may have a beneficial effect on their survival and cancer recurrence. This article summarizes the effects of local anesthetics in vitro (Tab. 1, Fig. 1, Ref. 36). Keywords: local anesthetics, cancer cells.
在癌症手术中，围手术期的特点是应激反应和免疫抑制，这可能导致疾病进一步恶化和转移扩散。局部麻醉药在体外对癌细胞具有抗增殖、细胞毒性和抗转移作用。有科学证据表明，局部麻醉药具有抗炎作用，有助于维持正常的免疫功能，并降低转移扩散的可能性。麻醉护理会影响疼痛、炎症和免疫抑制，这可能对肿瘤患者的结局产生重大影响。在肿瘤患者的围手术期使用局部麻醉药可能对其生存和癌症复发产生有益影响。本文总结了局部麻醉药在体外的作用（表 1、图 1、参考文献 36）。关键词：局部麻醉药、癌细胞。
