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肠道乳杆菌通过宿主-微生物视黄酸生物合成来激活上皮细胞抑制与结肠炎相关的 Th17 反应。

Lactobacillus Intestinalis Primes Epithelial Cells to Suppress Colitis-Related Th17 Response by Host-Microbe Retinoic Acid Biosynthesis.

机构信息

Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang, 310058, China.

Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058, China.

出版信息

Adv Sci (Weinh). 2023 Dec;10(36):e2303457. doi: 10.1002/advs.202303457. Epub 2023 Nov 20.

DOI:10.1002/advs.202303457
PMID:37983567
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10754072/
Abstract

Gut microbiome is integral to the pathogenesis of ulcerative colitis. A novel probiotic Lactobacillus intestinalis (L. intestinalis) exerts a protective effect against dextran sodium sulfate-induced colitis in mice. Based on flow cytometry, colitis-associated Th17 cells are the target of L. intestinalis, which is supported by the lack of protective effects of L. intestinalis in T cell-null Rag1 mice or upon anti-IL-17-A antibody-treated mice. Although L. intestinalis exerts no direct effect on T cell differentiation, it decreases C/EBPA-driven gut epithelial SAA1 and SAA2 production, which in turn impairs Th17 cell differentiation. Cometabolism of L. intestinalis ALDH and host ALDH1A2 contributed to elevated biosynthesis of retinoic acid (RA), which accounts for the anti-colitis effect in RAR-α -mediated way. In a cohort of ulcerative colitis patients, it is observed that fecal abundance of L. intestinalis is negatively associated with the C/EBPA-SAA1/2-Th17 axis. Finally, L. intestinalis has a synergistic effect with mesalazine in alleviating murine colitis. In conclusion, L. intestinalis and associated metabolites, RA, have potential therapeutic effects for suppressing colonic inflammation by modulating the crosstalk between intestinal epithelia and immunity.

摘要

肠道微生物群是溃疡性结肠炎发病机制的重要组成部分。一种新型益生菌——肠道乳杆菌（L. intestinalis）对葡聚糖硫酸钠诱导的小鼠结肠炎具有保护作用。基于流式细胞术，结肠炎相关的 Th17 细胞是 L. intestinalis 的作用靶点，这一作用在 T 细胞缺失 Rag1 小鼠或经抗 IL-17-A 抗体处理的小鼠中缺乏保护作用得到支持。尽管 L. intestinalis 对 T 细胞分化没有直接影响，但它可降低 C/EBPA 驱动的肠道上皮 SAA1 和 SAA2 的产生，进而损害 Th17 细胞分化。肠道乳杆菌 ALDH 和宿主 ALDH1A2 的共代谢作用导致视黄酸（RA）的生物合成增加，这解释了 RAR-α 介导的抗结肠炎作用。在溃疡性结肠炎患者队列中，观察到肠道乳杆菌的粪便丰度与 C/EBPA-SAA1/2-Th17 轴呈负相关。最后，肠道乳杆菌与美沙拉嗪在缓解小鼠结肠炎方面具有协同作用。总之，肠道乳杆菌及其相关代谢物 RA 通过调节肠道上皮与免疫之间的相互作用，具有抑制结肠炎症的潜在治疗作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4408/10754072/941d39eddfc4/ADVS-10-2303457-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4408/10754072/b8d4e32f05be/ADVS-10-2303457-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4408/10754072/5077604de58e/ADVS-10-2303457-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4408/10754072/d95001602d9f/ADVS-10-2303457-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4408/10754072/b8e8e45bc99a/ADVS-10-2303457-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4408/10754072/1f5bd3e578cc/ADVS-10-2303457-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4408/10754072/941d39eddfc4/ADVS-10-2303457-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4408/10754072/b8d4e32f05be/ADVS-10-2303457-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4408/10754072/5077604de58e/ADVS-10-2303457-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4408/10754072/d95001602d9f/ADVS-10-2303457-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4408/10754072/b8e8e45bc99a/ADVS-10-2303457-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4408/10754072/1f5bd3e578cc/ADVS-10-2303457-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4408/10754072/941d39eddfc4/ADVS-10-2303457-g001.jpg

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本文引用的文献

[1]
Variants in reveal an anti-inflammatory role for retinoic acid and a new class of disease-modifying drugs in osteoarthritis.

Sci Transl Med. 2022-12-21

[2]
Gut commensals expand vitamin A metabolic capacity of the mammalian host.

Cell Host Microbe. 2022-8-10

[3]
Intestinal butyrate-metabolizing species contribute to autoantibody production and bone erosion in rheumatoid arthritis.

Sci Adv. 2022-2-11

[4]
Human gut bacterial metabolism drives Th17 activation and colitis.

Cell Host Microbe. 2022-1-12

[5]
Commensal segmented filamentous bacteria-derived retinoic acid primes host defense to intestinal infection.

Cell Host Microbe. 2021-12-8

[6]
Oral Delivery of Encapsulated All-Trans Retinoic Acid Ameliorates Disease in Rodent Models of Colitis.

Inflamm Bowel Dis. 2022-3-2

[7]
Enterotoxigenic Bacteroidesfragilis Promotes Intestinal Inflammation and Malignancy by Inhibiting Exosome-Packaged miR-149-3p.

Gastroenterology. 2021-11

[8]
Serum Amyloid A Promotes Inflammation-Associated Damage and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer.

Cell Mol Gastroenterol Hepatol. 2021

[9]
The IL23-IL17 Immune Axis in the Treatment of Ulcerative Colitis: Successes, Defeats, and Ongoing Challenges.

Front Immunol. 2021

[10]
The Microbiome as a Therapy in Pouchitis and Ulcerative Colitis.

Nutrients. 2021-5-23

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