Clinical Microbiology Department, Hospital Universitario La Paz, IdiPaz, Madrid, Spain.
Clinical Microbiology Department, Hospital Universitario La Paz, IdiPaz, Madrid, Spain; CIBERINFEC, Instituto de Salud Carlos III, Madrid, Spain.
Anaerobe. 2023 Dec;84:102803. doi: 10.1016/j.anaerobe.2023.102803. Epub 2023 Nov 19.
Infections from anaerobic microorganisms result from breached mucosal barriers, posing a significant mortality risk. A retrospective study at Hospital Universitario La Paz (Madrid) from 2010 to 2022 analyzed 491 (6.17 %) anaerobic bacteremia cases out of 7956 significant bacteremia cases among 171,833 blood culture requests. Bacteroides fragilis was the most frequently isolated species (28.3 %), followed by Clostridium perfringens (13.6 %). B. fragilis showed good susceptibility to amoxicillin/ clavulanic acid (86 %), piperacillin/tazobactam (86 %), and metronidazole (87.7 %). In general, non-fragilis Bacteroides species showed low susceptibility to penicillin (7 %), amoxicillin (17.5 %), and clindamycin (64.9 %). Of our 13 non-perfringens Clostridium isolates, four exhibited resistance to penicillin and four showed resistance to clindamycin. Lactobacillus species were highly susceptible to antibiotics tested. Prevotella spp. showed low susceptibility to penicillin (20 %), amoxicillin (20 %), and clindamycin (40 %). The study contributes valuable data for monitoring and improving anaerobic bacteremia treatment.
从厌氧微生物引起的感染是由于粘膜屏障破裂所致，这带来了重大的死亡风险。马德里拉帕兹大学医院（Hospital Universitario La Paz）在 2010 年至 2022 年期间对 171833 份血培养请求中的 7956 份重要菌血症病例进行了回顾性研究，发现 491 例（6.17%）为厌氧菌血症。脆弱拟杆菌是最常分离到的菌种（28.3%），其次是产气荚膜梭菌（13.6%）。脆弱拟杆菌对阿莫西林/克拉维酸（86%）、哌拉西林/他唑巴坦（86%）和甲硝唑（87.7%）具有良好的敏感性。一般来说，非脆弱拟杆菌属的拟杆菌对青霉素（7%）、阿莫西林（17.5%）和克林霉素（64.9%）的敏感性较低。在我们的 13 株非产气荚膜梭菌中，有 4 株对青霉素和 4 株对克林霉素耐药。乳酸杆菌属对所测试的抗生素高度敏感。普雷沃氏菌属对青霉素（20%）、阿莫西林（20%）和克林霉素（40%）的敏感性较低。该研究为监测和改善厌氧菌血症治疗提供了有价值的数据。
