Kravchenko L V, Tutelyan V A, Vasilyev A V, Kranauskas A E, Avrenyeva L I
Toxicology. 1986 Dec 1;42(1):77-83. doi: 10.1016/0300-483x(86)90094-6.
The intragastric administration to male Wistar rats of T-2 toxin at 1-1.3 mg/kg body weight for 7 days caused a sharp decrease in the liver activity of lysosomal enzymes: beta-galactosidase, beta-N-acetylglucosaminidase, alpha-mannosidase, cathepsins A, B, C and D and in the activity of enzymes of the 1st phase of metabolism of xenobiotics--aniline hydroxylase and carboxylesterase, as well as in the cytochrome P-450 level. At the same time, the subacute toxic effect of T-2 toxin was manifested in a significant increase in the activity of epoxide hydrolase and an enzyme of the 2nd phase of metabolism of xenobiotics--UDP-glucuronosyltransferase. A possible mechanism of the observed enzymological changes is discussed.
以1 - 1.3毫克/千克体重的剂量对雄性Wistar大鼠进行为期7天的胃内给予T-2毒素，导致溶酶体酶（β-半乳糖苷酶、β-N-乙酰葡糖胺酶、α-甘露糖苷酶、组织蛋白酶A、B、C和D）的肝脏活性急剧下降，同时导致外源性物质代谢第一阶段的酶（苯胺羟化酶和羧酸酯酶）活性以及细胞色素P-450水平下降。与此同时，T-2毒素的亚急性毒性作用表现为环氧化物水解酶和外源性物质代谢第二阶段的一种酶（UDP-葡糖醛酸基转移酶）的活性显著增加。文中讨论了所观察到的酶学变化的可能机制。
