Mental Health Center of Xiangya Hospital, Central South University, Changsha 410008, Hunan, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China; Eye Center of Xiangya Hospital, Central South University, Changsha, China; Hunan Key Laboratory of Ophthalmology, Central South University, Changsha, China; National Key Clinical Ophthalmology Specialist, Xiangya Hospital, Central South University, Changsha, China; Hunan Provincial Branch of the National Clinical Medical Research Center for Eye Diseases, Xiangya Hospital, Central South University, Changsha, China.
J Affect Disord. 2024 Feb 15;347:8-14. doi: 10.1016/j.jad.2023.11.031. Epub 2023 Nov 18.
Research has shown the diagnostic potential of optical coherence tomography (OCT) and OCT angiography (OCTA) in various psychiatric disorders. However, there is few research focusing on changes specific to Major Depressive Disorder (MDD), and the diagnostic value of OCT combined with OCTA parameters for MDD remains unclear.
In this study, we investigated microvascular and morphology changes in the retina of MDD patients using a combination of OCTA and OCT parameters, and to examine their correlation with MDD mood and cognitive function in order to assess their diagnostic capability.
Our findings revealed a significant decline in macular vessel density (MVD) in the superficial retinal capillary plexus (SRCP) across all subfields, except the NO area. We also observed a significant positive correlation between fovea and Stroop-1, as well as between temporal inner (TI) and Stroop-3 in MDD patients. Furthermore, we identified a negative correlation between fovea and Self-Rating Depression Scale, as well as between Superior outer (SO) and Difficulties in Emotion Regulation Scale-C in MDD patients.
The sample size was small. Anatomical variables in blood flow may contribute to variability between subjects and outcomes.
The diagnostic value of OCTA suggests their potential as valuable tools for monitoring and diagnosing MDD.
研究表明，光学相干断层扫描（OCT）和 OCT 血管造影（OCTA）在各种精神疾病中有诊断潜力。然而，很少有研究关注特定于重度抑郁症（MDD）的变化，并且 OCT 结合 OCTA 参数对 MDD 的诊断价值尚不清楚。
在这项研究中，我们使用 OCTA 和 OCT 参数联合研究 MDD 患者视网膜的微血管和形态变化，并检查它们与 MDD 情绪和认知功能的相关性，以评估它们的诊断能力。
我们的研究结果表明，MDD 患者除了 NO 区外，所有亚区的浅层视网膜毛细血管丛（SRCP）的黄斑血管密度（MVD）都显著下降。我们还观察到 MDD 患者中黄斑和 Stroop-1 之间，以及颞内（TI）和 Stroop-3 之间存在显著的正相关。此外，我们发现 MDD 患者的黄斑与自我评估抑郁量表之间存在负相关，以及 Superior outer（SO）与情绪调节困难量表-C 之间存在负相关。
样本量小。血流的解剖变量可能会导致受试者和结果之间的变异性。
OCTA 的诊断价值表明其作为监测和诊断 MDD 的有价值工具的潜力。
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