Eye Center of Xiangya Hospital, Central South University, Changsha, China.
Hunan Key Laboratory of Ophthalmology, Central South University, Changsha, China.
CNS Neurosci Ther. 2024 Mar;30(3):e14699. doi: 10.1111/cns.14699.
Optical coherence tomography (OCT) or OCT angiography (OCTA) has been investigated in few research studies of psychiatric disorders. No research has been done using OCT or OCTA in patients with borderline personality disorder (BPD).
OCTA measured foveal avascular zone (FAZ), macular vessel density (MVD), and peripapillary vessel density (PVD). OCT measured the peripapillary retinal fiber layer (RNFL) and central retinal thickness (CRT). The study utilized the Ottawa Self-Injury Inventory, Hamilton Anxiety Rating Scale (HAMA), and Global Assessment of Functioning (GAF) to assess the symptom characteristics of individuals with BPD.
Fifty-nine eyes of BPD patients and 58 eyes of normal subjects were analyzed, MVD of the superficial retinal capillary plexus declined noticeably in most subfields (p < 0.05). Significant differences were observed in the whole inner ring and outer ring index between BPD and HC groups (p < 0.05). The patients with BPD exhibited lower RNFL and CRT, the difference was significant (p < 0.05). CRT indicated a significant negative correlation with the Ottawa Self-Injury Inventory (p < 0.05). In addition, we observed that there was a negative correlation identified between the MVD of the inner ring and HAMA (p < 0.05). Meanwhile, the MVD of the outer ring was positively correlated with GAF (p < 0.05). The areas under the receiver operating characteristic curves (AUROCs) for distinguishing BPD and HC eyes in OCTA were the highest for fovea MVD (0.679), followed by outer ring MVD (0.669), inner ring MVD (0.641), FAZ (0.579). In OCT, CRT was highest for BPD (0.711), followed by RNFL (0.625).
The OCT and OCTA can non-invasively detect microvascular and morphology changes of the retina in BPD patients compared to healthy control subjects.
光学相干断层扫描（OCT）或 OCT 血管造影（OCTA）已在一些精神疾病的研究中进行了研究。目前还没有针对边缘型人格障碍（BPD）患者使用 OCT 或 OCTA 的研究。
OCTA 测量了黄斑中心凹无血管区（FAZ）、黄斑血管密度（MVD）和视盘周围血管密度（PVD）。OCT 测量了视盘周围视网膜神经纤维层（RNFL）和中心视网膜厚度（CRT）。该研究使用渥太华自我伤害清单、汉密尔顿焦虑量表（HAMA）和总体功能评估（GAF）评估 BPD 个体的症状特征。
分析了 59 只 BPD 患者和 58 只正常对照者的眼睛，浅层视网膜毛细血管丛的 MVD 在大多数亚区明显下降（p<0.05）。BPD 组与 HC 组的全内环和外环指数差异有统计学意义（p<0.05）。BPD 患者的 RNFL 和 CRT 较低，差异有统计学意义（p<0.05）。CRT 与渥太华自我伤害清单呈显著负相关（p<0.05）。此外，我们观察到内环的 MVD 与 HAMA 之间存在负相关（p<0.05）。同时，外环的 MVD 与 GAF 呈正相关（p<0.05）。OCTA 区分 BPD 眼和 HC 眼的受试者工作特征曲线下面积（AUROCs）以黄斑 MVD 最高（0.679），其次是外环 MVD（0.669）、内环 MVD（0.641）、FAZ（0.579）。在 OCT 中，CRT 对 BPD 的分辨力最高（0.711），其次是 RNFL（0.625）。
与健康对照组相比，OCT 和 OCTA 可以非侵入性地检测 BPD 患者视网膜的微血管和形态变化。
