Lack of effect of short-term treatment with high doses of gentamicin on the level and subcellular distribution of cholesterol in rat kidney cortex.

Treatment of rats with 100 mg gentamicin sulfate/kg body weight by intraperitoneal injection once or twice daily for 3 days had no effect on the level of cholesterol in the kidney cortex, indicating that gentamicin does not affect the metabolism of this lipid under these conditions. Nor did such treatment cause any major subcellular redistribution of cholesterol in the kidney cortex, i.e., processes such as intracellular membrane traffic did not seem to be disturbed.