Abrar S S, Norsa'adah Bachok, Yahya Maya Mazuwin, Isa Junaidi A, Zon Erinna M
Unit of Biostatistics and Research Methodology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Malaysia.
Universiti Sains Malaysia Hospital, Kota Bharu, Malaysia.
Obstet Gynecol Sci. 2024 Jan;67(1):76-85. doi: 10.5468/ogs.23151. Epub 2023 Nov 21.
Pregnancy-associated breast cancer (PABC) is a rare cancer. This study aimed to determine the survival probabilities and prognostic factors in patients with PABC.
A retrospective cohort study was conducted in two tertiary care hospitals in Kota Bharu. We included all patients with breast cancer who were diagnosed by histopathology while pregnant or within 2 years post-partum from 2001 through 2020. We matched patients with PABC to non-pregnant patients with breast cancer by age and year of diagnosis. The data were analyzed using Cox proportional hazard regression.
A total of 35 cases of PABC and 70 non-PABC controls were recruited. The 3-year, 5-year, and 10-year survival probabilities for patients with PABC were 58.6%, 47.54%, and 38.03%, respectively. The patients with PABC had a non-significant difference in survival probabilities compared with non-PABC patients. The significant prognostic factors of PABC were age (adjusted hazard ratio [aHR], 0.91; 95% confidence interval [CI], 0.86-0.96; P=0.001), advanced stage of cancer (aHR, 9.97; 95% CI, 3.96-25.2; P<0.001), and no surgery (aHR, 3.16; 95% CI, 1.01-9.85; P=0.047). Pregnancy was not found to be an independent factor in the prognosis of PABC (aHR, 0.72; 95% CI, 0.39-1.28; P=0.266).
Women diagnosed with PABC had similar survival probabilities compared with non-PABC patients. Pregnancy was not an independent prognostic factor for breast cancer. This information can be useful when women with breast cancer are counseled and supported with the option of beginning treatment with pregnancy continuation.
妊娠相关乳腺癌（PABC）是一种罕见的癌症。本研究旨在确定PABC患者的生存概率和预后因素。
在哥打巴鲁的两家三级护理医院进行了一项回顾性队列研究。我们纳入了2001年至2020年期间在孕期或产后2年内经组织病理学诊断为乳腺癌的所有患者。我们根据年龄和诊断年份将PABC患者与非妊娠乳腺癌患者进行匹配。使用Cox比例风险回归分析数据。
共招募了35例PABC患者和70例非PABC对照。PABC患者的3年、5年和10年生存概率分别为58.6%、47.54%和38.03%。与非PABC患者相比，PABC患者的生存概率无显著差异。PABC的显著预后因素为年龄（调整后风险比[aHR]，0.91；95%置信区间[CI]，0.86 - 0.96；P = 0.001）、癌症晚期（aHR，9.97；95% CI，3.96 - 25.2；P < 0.001）和未进行手术（aHR，3.16；95% CI，1.01 - 9.85；P = 0.047）。未发现妊娠是PABC预后的独立因素（aHR，0.72；95% CI，0.39 - 1.28；P = 0.266）。
与非PABC患者相比，被诊断为PABC的女性生存概率相似。妊娠不是乳腺癌的独立预后因素。当为乳腺癌女性提供关于继续妊娠并开始治疗的选择的咨询和支持时，这些信息可能会有所帮助。
