对亲代骨髓移植的混合抗性：非同基因环境中造血干细胞的适应性修饰。
Hybrid resistance to parental bone marrow transplantation: adaptive modification of hemopoietic stem cell in a nonsyngeneic environment.
作者信息
Chertkov J L, Gelfand I M, Gurevitch O A, Lemeneva L N, Udalov G A
出版信息
Proc Natl Acad Sci U S A. 1979 Jun;76(6):2955-9. doi: 10.1073/pnas.76.6.2955.
Defective growth of parental bone marrow in an F1 hybrid is associated with delay of the exponential growth phase of injected hemopoietic stem cells rather than with their rejection. This is demonstrated both by parental hemopoietic stem cell kinetics in the irradiated hybrid and by the increase in the number of spleen colonies with time after hemopoietic cell injection. After passage through an F1 hybrid the parental hemopoietic stem cells acquire ability for better growth in the same F1 host. This phenomenon, which we designated "adaptive modification of hemopoietic stem cells," is associated with the appearance, on their surface, of histocompatibility molecules carrying H-2 determinants of the recipient. Treatment of the modified cells with antiserum against the second parental strain abrogates the state of adaptive modification.
F1杂种中亲代骨髓生长缺陷与注入的造血干细胞指数生长期延迟有关，而非与它们被排斥有关。这一点在受照射杂种中的亲代造血干细胞动力学以及造血细胞注射后脾脏集落数量随时间的增加中都得到了证明。亲代造血干细胞经过F1杂种后，在同一F1宿主体内获得了更好的生长能力。我们将这种现象称为“造血干细胞的适应性修饰”，它与细胞表面出现携带受体H-2决定簇的组织相容性分子有关。用针对第二种亲代品系的抗血清处理修饰后的细胞，可消除适应性修饰状态。
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