[骨/软骨免疫调节水凝胶：构建策略与应用]
[Bone/cartilage immunomodulating hydrogels: construction strategies and applications].
作者信息
Li Maoyuan, Zheng Guoshuang, Yang Jiahui, Chen Xiaofang, Xu Jianfeng, Zhao Dewei
机构信息
Zhongshan Clinical College of Dalian University, Dalian Liaoning, 116001, P. R. China.
Department of Orthopaedics, Zhongshan Hospital, Dalian University, Dalian Liaoning, 116001, P. R. China.
出版信息
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2023 Nov 15;37(11):1423-1430. doi: 10.7507/1002-1892.202305081.
OBJECTIVE
To review the research progress in the construction strategy and application of bone/cartilage immunomodulating hydrogels.
METHODS
The literature related to bone/cartilage immunomodulating hydrogels at home and abroad in recent years was reviewed and summarized from the immune response mechanism of different immune cells, the construction strategy of immunomodulating hydrogels, and their practical applications.
RESULTS
According to the immune response mechanism of different immune cells, the biological materials with immunoregulatory effect is designed, which can regulate the immune response of the body and thus promote the regeneration of bone/cartilage tissue. Immunomodulating hydrogels have good biocompatibility, adjustability, and multifunctionality. By regulating the physical and chemical properties of hydrogel and loading factors or cells, the immune system of the body can be purposively regulated, thus forming an immune microenvironment conducive to osteochondral regeneration.
CONCLUSION
Immunomodulating hydrogels can promote osteochondral repair by affecting the immunomodulation process of host organs or cells. It has shown a wide application prospect in the repair of osteochondral defects. However, more data support from basic and clinical experiments is needed for this material to further advance its clinical translation process.
目的
综述骨/软骨免疫调节水凝胶构建策略及应用的研究进展。
方法
从不同免疫细胞的免疫应答机制、免疫调节水凝胶的构建策略及其实际应用等方面，对近年来国内外与骨/软骨免疫调节水凝胶相关的文献进行回顾与总结。
结果
根据不同免疫细胞的免疫应答机制，设计出具有免疫调节作用的生物材料，可调节机体的免疫反应，从而促进骨/软骨组织再生。免疫调节水凝胶具有良好的生物相容性、可调节性和多功能性。通过调节水凝胶的物理化学性质以及负载因子或细胞，可有意地调节机体免疫系统，从而形成有利于骨软骨再生的免疫微环境。
结论
免疫调节水凝胶可通过影响宿主器官或细胞的免疫调节过程促进骨软骨修复。其在骨软骨缺损修复方面已展现出广阔的应用前景。然而，该材料还需要更多基础和临床实验的数据支持，以进一步推进其临床转化进程。
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