Section for Orthodontics, Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark.
Department of Oral and Maxillofacial Surgery, Aarhus University Hospital, Aarhus, Denmark.
Orthod Craniofac Res. 2024 Jun;27 Suppl 1:131-140. doi: 10.1111/ocr.12729. Epub 2023 Nov 21.
The study aimed to summarize current knowledge regarding the use of orthopaedic functional appliances (OFA) in managing unilateral craniofacial microsomia (UCM). The eligibility criteria for the review were (1) assessing use of OFA as a stand-alone treatment and (2) using OFA in combination during or after MDO. The PICO (population, intervention, comparison and outcome) format formulated clinical questions with defined inclusion and exclusion criteria. No limitations concerning language and publication year were applied. Information sources: A literature search of Medline, Scopus, Embase, Cochrane Central Register of Controlled Trials, Web of Science databases without restrictions up to 30 September 2022. The risk of bias was assessed. According to Cochrane and PRISMA guidelines, two independent authors conducted data extraction. The level of evidence for included articles was evaluated based on the Oxford evidence-based medicine database. Due to the heterogeneity of studies and insufficient data for statistical pooling, meta-analysis was not feasible. Therefore, the results were synthesized narratively. A total of 437 articles were retrieved. Of these, nine met inclusion criteria: five assessing OFA and four assessing OFA during or after MDO. There is limited evidence to suggest that stand-alone and combination treatment with OFA is beneficial for treating mild-to-moderate UCM-related dentofacial deformities in short term. No studies assessed the burden of care. In the management of UCM, there is insufficient evidence supporting the efficacy of OFA as a stand-alone treatment or when combined with MDO. Additionally, there is a lack of evidence regarding treatment protocols and the effect on the condyles and the TMJ. The study was registered at Prospero database number CRD42020204969.
本研究旨在总结目前关于使用矫形功能性矫治器（OFA）治疗单侧颅面短小症（UCM）的知识。本综述的纳入标准为：（1）评估 OFA 作为单一疗法的使用情况；（2）在 MDO 期间或之后联合使用 OFA。PICO（人群、干预、比较和结果）格式制定了具有明确纳入和排除标准的临床问题。未对语言和出版年份施加任何限制。信息来源：对 Medline、Scopus、Embase、Cochrane 对照试验中心注册库、Web of Science 数据库进行了无限制的文献检索，检索时间截至 2022 年 9 月 30 日。评估了偏倚风险。根据 Cochrane 和 PRISMA 指南，两名独立的作者进行了数据提取。根据牛津循证医学数据库，评估了纳入文章的证据水平。由于研究的异质性和统计汇总数据不足，因此无法进行荟萃分析。因此，结果以叙述性方式进行综合。共检索到 437 篇文章。其中，有 9 篇符合纳入标准：5 篇评估 OFA，4 篇评估 MDO 期间或之后的 OFA。有有限的证据表明，OFA 单独使用和联合使用对治疗轻度至中度 UCM 相关的牙颌面畸形在短期是有益的。没有研究评估护理负担。在 UCM 的治疗中，缺乏支持 OFA 作为单一疗法或与 MDO 联合使用的疗效的证据。此外，关于治疗方案以及对髁突和 TMJ 的影响的证据也不足。本研究已在 Prospero 数据库中注册，编号为 CRD42020204969。
