Yeung Chris Ho Ching, Bauer Cici, Xiao Qian
Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Department of Biostatistics and Data Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Clocks Sleep. 2023 Nov 2;5(4):667-685. doi: 10.3390/clockssleep5040045.
Liver functions are regulated by the circadian rhythm; however, whether a weakened circadian rhythm is associated with impaired liver function is unclear. This study aims to investigate the association of characteristics of rest-activity rhythms with abnormal levels of biomarkers of liver function. Data were obtained from the National Health and Nutrition Examination Survey 2011-2014. Seven rest-activity rhythm parameters were derived from 24 h actigraphy data using the extended cosine model and non-parametric methods. Multiple logistic regression and multiple linear regression models were used to assess the associations between rest-activity rhythm parameters and alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma-glutamyl transaminase (GGT), albumin and bilirubin. Weakened overall rhythmicity characterized by a lower F statistic was associated with higher odds of abnormally elevated ALP (OR: 2.16; 95% CI 1.19, 3.90) and GGT (OR: 2.04; 95% CI 1.30, 3.20) and abnormally lowered albumin (OR: 5.15; 95% CI 2.14, 12.38). Similar results were found for a lower amplitude, amplitude:mesor ratio, interdaily stability and intradaily variability. Results were robust to the adjustment of confounders and cannot be fully explained by individual rest-activity behaviors, including sleep and physical activity. Weakened rest-activity rhythms were associated with worse liver function as measured by multiple biomarkers, supporting a potential role of circadian rhythms in liver health.
肝脏功能受昼夜节律调节；然而，昼夜节律减弱是否与肝功能受损相关尚不清楚。本研究旨在调查静息-活动节律特征与肝功能生物标志物异常水平之间的关联。数据来自2011 - 2014年国家健康与营养检查调查。使用扩展余弦模型和非参数方法从24小时活动记录仪数据中得出七个静息-活动节律参数。采用多元逻辑回归和多元线性回归模型评估静息-活动节律参数与丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、碱性磷酸酶（ALP）、γ-谷氨酰转移酶（GGT）、白蛋白和胆红素之间的关联。以较低的F统计量为特征的整体节律性减弱与ALP异常升高（OR：2.16；95%CI 1.19，3.90）、GGT异常升高（OR：2.04；95%CI 1.30，3.20）以及白蛋白异常降低（OR：5.15；95%CI 2.14，12.38）的较高几率相关。较低的振幅、振幅与中值比、日间稳定性和日内变异性也得到了类似结果。结果在调整混杂因素后依然稳健，且不能完全由包括睡眠和身体活动在内的个体静息-活动行为来解释。通过多种生物标志物测量发现，减弱的静息-活动节律与较差的肝功能相关，这支持了昼夜节律在肝脏健康中的潜在作用。
