Division of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Goldbelt C6, LLC, Chesapeake, Virginia, USA.
Microb Genom. 2023 Nov;9(11). doi: 10.1099/mgen.0.001119.
Carbapenem-resistant (CRE) are an urgent public health threat. Genomic sequencing is an important tool for investigating CRE. Through the Division of Healthcare Quality Promotion Sentinel Surveillance system, we collected CRE and carbapenem-susceptible (CSE) from nine clinical laboratories in the USA from 2013 to 2016 and analysed both phenotypic and genomic sequencing data for 680 isolates. We describe the molecular epidemiology and antimicrobial susceptibility testing (AST) data of this collection of isolates. We also performed a phenotype-genotype correlation for the carbapenems and evaluated the presence of virulence genes in complex isolates. These AST and genomic sequencing data can be used to compare and contrast CRE and CSE at these sites and serve as a resource for the antimicrobial resistance research community.
耐碳青霉烯类肠杆菌科细菌（CRE）是一个紧迫的公共卫生威胁。基因组测序是研究 CRE 的重要工具。通过医疗保健质量促进部门的监测系统，我们从美国的九个临床实验室收集了 2013 年至 2016 年的耐碳青霉烯类肠杆菌科细菌和碳青霉烯类敏感菌（CSE），并对 680 株分离株的表型和基因组测序数据进行了分析。我们描述了该分离株的分子流行病学和抗菌药物敏感性测试（AST）数据。我们还对碳青霉烯类药物进行了表型-基因型相关性分析，并评估了复杂分离株中毒力基因的存在。这些 AST 和基因组测序数据可用于比较和对比这些地点的 CRE 和 CSE，并为抗菌药物耐药性研究界提供资源。
