Animal Production Department, Fac. of Agriculture, Assiut University, Assiut, Egypt.
Pathology Department, Institute of Veterinary Health, Assiut, Egypt.
Anim Reprod Sci. 2023 Dec;259:107378. doi: 10.1016/j.anireprosci.2023.107378. Epub 2023 Nov 17.
Oxidative status is important in reproductive performance and using two natural antioxidants is more beneficial than one in nulliparous rabbits. The goal, effect of vitamin E (VitE), D-limonene (DL), and VitE+DL on maternal LBW (MLBW), conception (CR), pregnancy (PR), and kindling rates (KR), gestation length (GL), total litter size at birth (TLSB) and weaning (TLSW), live kits at birth (LKB) and weaning (LKW), dead kits at birth (DKB) and weaning (DKW), kits mortality rate at weaning (KMRW), Kit weight at birth (KWB) and weaning (KWW), total kit weight at birth (TKWB) and weaning (TKWW), and concentrations of progesterone (P4) and Malondialdehyde (MDA), during first two pregnancies. A total of 24 healthy female WNZ rabbits were randomly selected and assigned into four groups (6/each). Control (animals injected with 1.0 mL propylene glycol), VitE (60 mg IM injection/animal, 2X/week pre-mating and 3X post-mating until mid-pregnancy, DL (20 mg IM injection/animal, 2X/week pre-mating and 1X at mating, and VitE+DL (IM injection/animal with the same doses and times applied in VitE and DL groups. All animals were treated during 1st pregnancy only. The results confirmed that animals treated with VitE+DL gained significant maternal LBW in 1st pregnancy, reduced dead kit number at birth and kit mortality rate at weaning, increased live kits and total kit weight at birth and weaning in the two pregnancies, and also increased significantly kit weight at birth and weaning in the treatments than controls in the two pregnancies, and DL was greater in 1st pregnancy. Progesterone concentrations in mid-pregnancy rose significantly in VitE+DL during 1st pregnancy and DL in 2nd pregnancy. Malondialdehyde concentrations dropped significantly in VitE and VitE+DL in mid-pregnancy in the two pregnancies. Eventually, the integration of VitE and DL displayed their unique properties for improving productive and reproductive performance in nulliparous rabbits.
氧化状态对繁殖性能很重要，使用两种天然抗氧化剂比使用一种更有益。本研究旨在探讨维生素 E（VitE）、D-柠檬烯（DL）和 VitE+DL 对初产母兔的低出生体重仔兔（MLBW）、配种（CR）、妊娠（PR）和产仔率（KR）、妊娠时间（GL）、总产仔数（TLSB）和断奶（TLSW）、初生活仔兔（LKB）和断奶（LKW）、初生死仔兔（DKB）和断奶（DKW）、断奶仔兔死亡率（KMRW）、初生仔兔体重（KWB）和断奶（KWW）、总初生仔兔体重（TKWB）和断奶（TKWW）以及孕酮（P4）和丙二醛（MDA）浓度的影响。选择 24 只健康的 WNZ 母兔，随机分为四组（每组 6 只）。对照组（动物注射 1.0ml 丙二醇）、VitE 组（60mg 肌肉注射/只，交配前 2 次/周，交配后 3 次/周，直至妊娠中期）、DL 组（20mg 肌肉注射/只，交配前 2 次/周，1 次交配时）、VitE+DL 组（动物肌肉注射相同剂量和时间 VitE 和 DL）。所有动物仅在第 1 次妊娠期间接受治疗。结果证实，VitE+DL 组的母兔在第 1 次妊娠时的低出生体重明显增加，出生时死仔数和断奶时仔兔死亡率降低，两次妊娠的初生和断奶活仔兔和总仔兔体重增加，与对照组相比，两次妊娠的初生和断奶仔兔体重均显著增加，DL 组在第 1 次妊娠时的增加量更大。第 1 次妊娠 VitE+DL 组和第 2 次妊娠 DL 组的妊娠中期孕酮浓度显著升高。两次妊娠的 VitE 和 VitE+DL 组在妊娠中期丙二醛浓度均显著下降。总之，VitE 和 DL 的联合使用表现出了其独特的特性，可提高初产母兔的生产和繁殖性能。
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