Hacettepe University, Faculty of Pharmacy, Department of Radiopharmacy, Ankara, Turkey.
Hacettepe University, Faculty of Medicine, Department of Nuclear Medicine, Ankara, Turkey.
Appl Radiat Isot. 2024 Jan;203:111110. doi: 10.1016/j.apradiso.2023.111110. Epub 2023 Nov 17.
Parkinson's disease (PD) is a widespread progressive neurodegenerative disease. Clinical diagnosis approaches are insufficient to provide an early and accurate diagnosis before a substantial of loss of dopaminergic neurons. PET and SPECT can be used for accurate and early diagnosis of PD by using target-specific radiotracers. Additionally, the importance of BBB penetrating targeted nanosystems has increased in recent years. This article reviews targeted radiopharmaceuticals used in clinics and novel nanocarriers for research purposes of PD imaging.
帕金森病（PD）是一种广泛存在的进行性神经退行性疾病。临床诊断方法不足以在多巴胺能神经元大量丧失之前提供早期和准确的诊断。正电子发射断层扫描（PET）和单光子发射计算机断层扫描（SPECT）可以通过使用靶特异性放射性示踪剂来进行 PD 的准确和早期诊断。此外，近年来穿透血脑屏障的靶向纳米系统的重要性有所增加。本文综述了用于临床的靶向放射性药物和用于 PD 成像研究的新型纳米载体。
