第三代狂犬病病毒载体作为逆行标记工具具有低毒性和更高的效率。
Third-generation rabies viral vectors have low toxicity and improved efficiency as retrograde labeling tools.
机构信息
Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
出版信息
Cell Rep Methods. 2023 Nov 20;3(11):100646. doi: 10.1016/j.crmeth.2023.100646.
Abstract
In this issue of Cell Reports Methods, Jin et al. report the generation and validation of a rabies variant, RVΔL, for projection-based neuronal labeling. RVΔL shows little toxicity in vivo and has an improved growth advantage over another variant, RVΔGL, making it a useful tool for a wide variety of systems neuroscience-based studies.
摘要
在本期《细胞报告方法》中，Jin 等人报道了一种用于基于Projection 的神经元标记的狂犬病毒变体 RVΔL 的产生和验证。RVΔL 在体内毒性较小，并且比另一种变体 RVΔGL 具有更好的生长优势，使其成为广泛的基于系统神经科学的研究的有用工具。
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