Department of Neonatal Surgery, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, 3333 Binsheng Rd, Hangzhou, Zhejiang, China.
Department of Cardiology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, 3333 Binsheng Rd, Hangzhou, Zhejiang, China.
BMC Pediatr. 2023 Nov 22;23(1):585. doi: 10.1186/s12887-023-04418-y.
The purpose of this study was to explore echocardiographic parameters of the left ventricle (LV) in relation to the outcomes of omphalocele neonates with pulmonary hypertension (PH).
This retrospective study was conducted among omphalocele patients with PH born from 2019 to 2020. Patients in this study did not have additional severe malformations or chromosomal aberrations. Patients who died under palliative care were excluded. The echocardiographic parameters of LV were obtained within 24 h after birth. Clinical and outcomes data were recorded, echocardiograms evaluated for left ventricular internal dimension in end-diastole (LVIDd), end-diastolic volume (EDV), stroke volume (SV) and cardiac output index (CI), among others.
There were 18 omphalocele newborns with PH, of whom 14 survived and 4 died. Both groups were comparable in the baseline characteristics. Non-survival was associated with a smaller LV [LVIDd (12.2 mm versus15.7 mm, p < 0.05), EDV (3.5 ml versus 6.8 ml, p < 0.05)] and with worse systolic function [SV (2.3 ml versus 4.2 ml, p < 0.05), and CI (1.7 L/min/m versus 2.9 L/min/m, p < 0.01)].
In the cohort of omphalocele patients with PH, lower LVIDd, EDV, SV and CI were associated with mortality.
Level III.
本研究旨在探讨与患有肺动脉高压（PH）的脐膨出新生儿结局相关的左心室（LV）超声心动图参数。
这是一项回顾性研究，纳入了 2019 年至 2020 年期间患有 PH 的脐膨出患者。本研究中的患者没有其他严重畸形或染色体异常。排除了在姑息治疗下死亡的患者。LV 的超声心动图参数是在出生后 24 小时内获得的。记录了临床和结局数据，并对左心室舒张末期内径（LVIDd）、舒张末期容积（EDV）、每搏输出量（SV）和心输出量指数（CI）等 LV 超声心动图参数进行了评估。
共有 18 例患有 PH 的脐膨出新生儿，其中 14 例存活，4 例死亡。两组在基线特征方面具有可比性。非存活组的 LV 较小[LVIDd（12.2mm 比 15.7mm，p<0.05），EDV（3.5ml 比 6.8ml，p<0.05）]，收缩功能更差[SV（2.3ml 比 4.2ml，p<0.05）和 CI（1.7L/min/m 比 2.9L/min/m，p<0.01）]。
在患有 PH 的脐膨出患者队列中，较低的 LVIDd、EDV、SV 和 CI 与死亡率相关。
III 级。
