National Clinical Research Center for Ocular Diseases (T.P., J.J.), Eye Hospital, Wenzhou Medical University, Wenzhou, China; and State Key Laboratory of Ophthalmology (T.P., J.J.), Optometry and Visual Science, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Eye Contact Lens. 2023 Dec 1;49(12):535-541. doi: 10.1097/ICL.0000000000001043. Epub 2023 Oct 2.
To evaluate ocular changes in Chinese myopic children wearing multifocal soft contact lenses and explore their efficiency and related factors.
This was a prospective, double-blind, randomized controlled study. A total of 36 myopic children aged 7 to 12 years were randomly divided into groups wearing multifocal soft contact lenses (MFCLs) or single-vision soft contact lenses (SVCLs) and followed up for 12 months. The spherical equivalent (SE), axial length (AL), choroidal thickness, and vascularity were measured before commencement and after 6 and 12 months of lens wear. Correlation between ocular changes and myopia progression was determined.
A total of 32 subjects (6 males and 26 females) completed the study and were included in the analysis. After 12 months of lens wear, both the AL elongation (0.25±0.22 vs. 0.43±0.16 mm, P=0.011) and the SE progression (-0.69±0.69 D vs. -1.45±0.56 D, P=0.002) of the MFCL group were significantly lower than those of the SVCL group. After 12 months, the progression of myopia was significantly correlated with changes of the choroid in the MFCL wearers, whereas no such correlation was observed in the SVCL group.
Multifocal soft contact lens can slow myopia progression, and this effect may be related to the changes of the choroid.
评估中国近视儿童佩戴多焦点软性隐形眼镜后的眼部变化，并探讨其有效性及相关因素。
这是一项前瞻性、双盲、随机对照研究。共 36 名 7 至 12 岁的近视儿童被随机分为多焦点软性隐形眼镜（MFCL）组或单焦点软性隐形眼镜（SVCL）组，并随访 12 个月。在开始佩戴镜片前以及佩戴 6 个月和 12 个月后，测量球镜等效（SE）、眼轴（AL）、脉络膜厚度和血管密度。确定眼部变化与近视进展的相关性。
共有 32 名受试者（6 名男性和 26 名女性）完成了研究并纳入分析。佩戴镜片 12 个月后，MFCL 组的 AL 伸长量（0.25±0.22 比 0.43±0.16 mm，P=0.011）和 SE 进展量（-0.69±0.69 D 比-1.45±0.56 D，P=0.002）均显著低于 SVCL 组。12 个月后，MFCL 佩戴者的脉络膜变化与近视进展显著相关，而 SVCL 组则无此相关性。
多焦点软性隐形眼镜可减缓近视进展，这种效果可能与脉络膜的变化有关。
