Department of Biomedical Engineering, and Department of Pharmaceutical Engineering, School of Engineering, China Pharmaceutical University, Nanjing, 211198, China.
Adv Healthc Mater. 2024 Mar;13(6):e2302721. doi: 10.1002/adhm.202302721. Epub 2023 Nov 29.
Multimodal biomedical imaging and imaging-guided therapy have garnered extensive attention owing to the aid of nanoagents with the aim of further improving the therapeutic efficacy of diseases. The ability to engineer nanocomplexes (NCs) or control how they behave within an organism remains largely elusive. Here, a multifunctional nanoplatform is developed based on stabilized I-doped perovskite, CsPbBr I @SiO @Lip-c(RGD) (PSL-c(RGD) ) NCs. In particular, by regulating the amount of regular I ions introduced, the fluorescence emission spectrum of perovskite-based NCs can be modulated well to match the requirement for biomedical optical imaging at the scale from molecule, cell to mouse; doping I enables the nanoformulation to be competent for single-photon emission computed tomography (SPECT) imaging; the introduction of I imparts the NCs with the capability for radiotherapy. Through facile manipulation of specific iodine ions, this nanoplatform exhibits a remarkable ability to match multifunctional biomedical imaging and tumor therapy. In addition, their in vivo behavior can be manipulated by adjusting the thickness of the silica shell and the surface polarity for more practical applications. These experimental explorations offer a novel approach for engineering desirable multimodal NCs to simultaneously image and combat malignant tumors.
多模态生物医学成像和成像引导治疗受到广泛关注，因为纳米制剂可以帮助进一步提高疾病的治疗效果。然而，设计纳米复合物（NCs）或控制它们在生物体中的行为仍然具有很大的挑战性。在此，我们基于稳定化 I 掺杂钙钛矿 CsPbBr I @SiO @Lip-c(RGD)（PSL-c(RGD)）NCs 开发了一种多功能纳米平台。具体而言，通过调节引入的常规 I 离子的数量，可以很好地调节基于钙钛矿的 NCs 的荧光发射光谱，以满足从分子、细胞到小鼠的生物医学光学成像的要求；I 掺杂使纳米制剂能够胜任单光子发射计算机断层扫描（SPECT）成像；引入 I 赋予 NCs 放射治疗的能力。通过对特定碘离子的简单操作，该纳米平台表现出了出色的多功能生物医学成像和肿瘤治疗匹配能力。此外，通过调整二氧化硅壳的厚度和表面极性，可以控制它们的体内行为，以实现更实际的应用。这些实验探索为设计理想的多模态 NCs 以同时进行成像和治疗恶性肿瘤提供了一种新方法。
