Department of Nephrology, the First People's Hospital of Jiashan, Zhejiang, China.
Department of Rehabilitation, the First People's Hospital of Jiashan, Zhejiang, China.
Int Wound J. 2024 Mar;21(3):e14409. doi: 10.1111/iwj.14409. Epub 2023 Nov 22.
The meta-analysis aimed to assess renal function (RF) as a risk factor for diabetic foot ulcers (DFUs). Using dichotomous or contentious random or fixed effect models, the outcomes of this meta-analysis were examined, and the odds Ratio (OR) and the mean difference (MD) with 95% confidence intervals (CIs) were computed. 16 examinations from 2004 to 2023 were enrolled for the present meta-analysis, including 808 914 individuals with diabetes mellitus (DM). DFU had significantly higher chronic renal failure (OR, 3.17; 95% CI, 1.97-5.09, p < 0.001), higher serum Creatinine (MD, 29.30; 95% CI, 9.68-48.92, p = 0.003), and a low estimated glomerular filtration rate (MD, -15.31; 95% CI, -19.36 to -11.26, p < 0.001) compared to non-DFU patients with DM. The examined data revealed that DFU had significantly higher chronic renal failure, higher serum Creatinine, and a low estimated glomerular filtration rate compared to non-DFU patients with DM. Yet, attention should be paid to its values since some comparisons had a low number of selected studies.
本荟萃分析旨在评估肾功能 (RF) 作为糖尿病足溃疡 (DFU) 的风险因素。使用二分类或有争议的随机或固定效应模型，检查了该荟萃分析的结果，并计算了优势比 (OR) 和 95%置信区间 (CI) 的均数差 (MD)。本荟萃分析纳入了 2004 年至 2023 年的 16 项研究，共纳入 808914 例糖尿病患者。DFU 患者慢性肾衰竭的发生率明显更高 (OR，3.17；95%CI，1.97-5.09，p<0.001)，血清肌酐更高 (MD，29.30；95%CI，9.68-48.92，p=0.003)，肾小球滤过率估计值更低 (MD，-15.31；95%CI，-19.36 至-11.26，p<0.001)，与非 DFU 糖尿病患者相比。检查数据显示，与非 DFU 糖尿病患者相比，DFU 患者慢性肾衰竭发生率更高，血清肌酐更高，肾小球滤过率估计值更低。然而，由于一些比较的研究数量较少，应该注意其价值。
