Rezaei Abedeh, Moqadami Amin, Khalaj-Kondori Mohammad
Department of Animal Biology¸ Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
Naunyn Schmiedebergs Arch Pharmacol. 2024 May;397(5):2835-2848. doi: 10.1007/s00210-023-02839-1. Epub 2023 Nov 22.
Minocycline is an FDA-approved secondary-generation tetracycline antibiotic. It is a synthetic antibiotic having many biological effects, such as antioxidant, anti-inflammatory, anti-cancer, and neuroprotective functions. This study discusses the pharmacological mechanisms of preventive and therapeutic effects of minocycline. Specifically, it provides a comprehensive overview of the molecular pathways by which minocycline acts on the different cancers, including ovarian, breast, glioma, colorectal, liver, pancreatic, lung, prostate, melanoma, head and neck, leukemia, and non-cancer diseases such as Alzheimer's disease, Parkinson, schizophrenia, multiple sclerosis, Huntington, polycystic ovary syndrome, and coronavirus disease 19. Minocycline may be a potential medication for these disorders due to its strong blood-brain barrier penetrance. It is also widely accepted as a specific medication, has a well-known side-effect characteristic, is reasonably priced, making it appropriate for continuous use in managing diseases, and has been demonstrated as an oral approach because it is effectively absorbed and accomplished almost all of the body's parts.
米诺环素是一种经美国食品药品监督管理局（FDA）批准的二代四环素类抗生素。它是一种具有多种生物学效应的合成抗生素，如抗氧化、抗炎、抗癌和神经保护功能。本研究讨论了米诺环素预防和治疗作用的药理机制。具体而言，它全面概述了米诺环素作用于不同癌症（包括卵巢癌、乳腺癌、胶质瘤、结直肠癌、肝癌、胰腺癌、肺癌、前列腺癌、黑色素瘤、头颈癌、白血病）以及非癌症疾病（如阿尔茨海默病、帕金森病、精神分裂症、多发性硬化症、亨廷顿病、多囊卵巢综合征和冠状病毒病19）的分子途径。由于米诺环素具有很强的血脑屏障穿透性，它可能是治疗这些疾病的一种潜在药物。它也被广泛认为是一种特效药物，具有众所周知的副作用特征，价格合理，适合在疾病管理中持续使用，并且已被证明是一种口服药物，因为它能有效吸收并几乎到达身体的所有部位。
