Hellberg D, Valentin J, Nilsson S
Acta Obstet Gynecol Scand. 1986;65(6):625-31. doi: 10.3109/00016348609158400.
The connection between smoking and cervical neoplasia has been questioned. The association demonstrated has been suspected to depend on a correlation between smoking and sexual behavior or other risk factors for cervical neoplasia. This case-control study included 140 women with cervical intraepithelial neoplasia diagnosed during pregnancy. For each case, 2 healthy, age-matched women, who simultaneously attended for a pregnancy check at the same maternity clinic, served as controls. Information was obtained on obstetrical and gynecological history, sexual behavior, contraceptive methods, female and male smoking habits and socioeconomic status, using both an interview and a questionnaire. The patients were significantly younger at first intercourse and first pregnancy, had more sexual partners, showed a higher frequency of both female and male smokers and had a different pattern of contraceptive use vis-á-vis the controls. Analyses of covariance were used to identify and check for possible confounding before a log-linear regression analysis was ultimately carried out. Two factors remained closely associated with cervical intraepithelial neoplasia: number of sexual partners, and female smoking. We conclude that smoking seems to be a genuine risk factor for cervical intraepithelial neoplasia.
吸烟与宫颈肿瘤之间的联系一直受到质疑。已证实的这种关联被怀疑取决于吸烟与性行为或其他宫颈肿瘤危险因素之间的相关性。这项病例对照研究纳入了140名在孕期被诊断为宫颈上皮内瘤变的女性。对于每一例病例，选取2名健康的、年龄匹配的女性作为对照，她们同时在同一家产科诊所进行孕期检查。通过访谈和问卷获取了有关妇产科病史、性行为、避孕方法、男女吸烟习惯以及社会经济状况的信息。病例组在首次性交和首次怀孕时明显更年轻，有更多性伴侣，男女吸烟者的比例更高，并且与对照组相比有不同的避孕方式。在最终进行对数线性回归分析之前，使用协方差分析来识别和检查可能的混杂因素。有两个因素与宫颈上皮内瘤变密切相关：性伴侣数量和女性吸烟。我们得出结论，吸烟似乎是宫颈上皮内瘤变的一个真正危险因素。
