Division of System Neurophysiology, National Institute for Physiological Sciences, Okazaki, Aichi 444-8585, Japan; Department of Physiological Sciences, SOKENDAI, Okazaki, Aichi 444-8585, Japan.
Division of System Neurophysiology, National Institute for Physiological Sciences, Okazaki, Aichi 444-8585, Japan; Department of Physiological Sciences, SOKENDAI, Okazaki, Aichi 444-8585, Japan.
Neurobiol Dis. 2024 Jan;190:106362. doi: 10.1016/j.nbd.2023.106362. Epub 2023 Nov 20.
The external segment of the globus pallidus (GPe) has long been considered a homogeneous structure that receives inputs from the striatum and sends processed information to the subthalamic nucleus, composing a relay nucleus of the indirect pathway that contributes to movement suppression. Recent methodological revolution in rodents led to the identification of two distinct cell types in the GPe with different fiber connections. The GPe may be regarded as a dynamic, complex and influential center within the basal ganglia circuitry, rather than a simple relay nucleus. On the other hand, many studies have so far been performed in monkeys to clarify the functions of the basal ganglia in the healthy and diseased states, but have not paid much attention to such classification and functional differences of GPe neurons. In this minireview, we consider the knowledge on the rodent GPe and discuss its impact on the understanding of the basal ganglia circuitry in monkeys.
苍白球外节（GPe）长期以来被认为是一个同质结构，它接收来自纹状体的输入，并将处理后的信息发送到丘脑下核，构成间接通路的中继核，有助于运动抑制。最近在啮齿动物中的方法学革命导致了在 GPe 中鉴定出两种具有不同纤维连接的不同细胞类型。GPe 可能被视为基底神经节回路中的一个动态、复杂和有影响力的中心，而不是一个简单的中继核。另一方面，迄今为止，许多研究都是在猴子中进行的，以阐明基底神经节在健康和患病状态下的功能，但没有太多关注 GPe 神经元的这种分类和功能差异。在这篇综述中，我们考虑了关于啮齿动物 GPe 的知识，并讨论了它对理解猴子基底神经节回路的影响。
