Ferenczi Emily A, Wang Wengang, Biswas Anushka, Pottala Trent, Dong Yihuan, Chan Alison K, Albanese Madeline A, Sohur Raina S, Jia Tingying, Mastro Kevin J, Sabatini Bernardo L
HHMI, Department of Neurobiology, Harvard Medical School, Boston MA 02115.
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.
Proc Natl Acad Sci U S A. 2025 Jun 10;122(23):e2423367122. doi: 10.1073/pnas.2423367122. Epub 2025 Jun 3.
The globus pallidus externa (GPe) is a heterogeneous nucleus of the basal ganglia, with intricate connections to other basal ganglia nuclei, as well as direct connections to the cortex. The anatomic, molecular, and electrophysiologic properties of cortex-projecting pallidocortical neurons are not well characterized. Here, we show that pallidocortical neurons project to diverse motor and nonmotor cortical regions, are organized topographically in the GPe, and segregate into at least two distinct electrophysiological and molecular phenotypes. In addition, we find that the GPe receives direct synaptic input from deep layers of diverse motor and nonmotor cortical regions, some of which form reciprocal connections onto pallidocortical neurons. These results demonstrate the existence of a fast, bidirectional circuit between the GPe and the cortex that is ideally positioned to integrate information about behavioral goals, internal states, and environmental cues to rapidly modulate behavior.
苍白球外侧部（GPe）是基底神经节的一个异质性核团，与其他基底神经节核团有着复杂的连接，并且与皮质有直接连接。投射到皮质的苍白球皮质神经元的解剖学、分子学和电生理学特性尚未得到充分表征。在此，我们表明苍白球皮质神经元投射到不同的运动和非运动皮质区域，在GPe中按拓扑结构组织，并分为至少两种不同的电生理和分子表型。此外，我们发现GPe接受来自不同运动和非运动皮质区域深层的直接突触输入，其中一些在苍白球皮质神经元上形成相互连接。这些结果证明了GPe与皮质之间存在一个快速的双向回路，该回路处于理想位置，能够整合有关行为目标、内部状态和环境线索的信息，以快速调节行为。
