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[翻译文章] 初次全髋关节置换术中使用模块化股骨柄后血清铬和钴水平的变化

[Translated article] Evolution of chromium and cobalt serum levels after the use of a modular neck stem in primary total hip arthroplasty.

作者信息

López R E, Pelayo de Tomás J M, Morales Suárez Varela M, Rodrigo Pérez J L

机构信息

Hospital Universitario Doctor Peset, Valencia, Spain.

Hospital Universitario Doctor Peset, Valencia, Spain; Facultad de Medicina, Universidad de Valencia, Valencia, Spain.

出版信息

Rev Esp Cir Ortop Traumatol. 2024 Jan-Feb;68(1):T26-T34. doi: 10.1016/j.recot.2023.11.010. Epub 2023 Nov 20.

Abstract

INTRODUCTION AND OBJECTIVES

Modular neck primary stems were introduced with the theoretical advantage of restoring the hip anatomy more precisely. However, the presence of a second junction has been associated with increased corrosion and release of metal debris. The objective of our study is to quantify of chromium and cobalt serum values, and to analyse their temporal evolution during five years.

MATERIAL AND METHODS

We present a prospective series of 61 patients who underwent primary total hip arthroplasty by implantation of the H MAX-M® stem (Limacorporate, San Daniele, Italy). Serum chromium and cobalt determinations were performed at six months, two years and five years.

RESULTS

Our series shows a progressive elevation in chromium levels with a significant difference between chromium values at six months (0.35±0.18) and five years (0.52±0.36), p=.01. Regarding cobalt, a statistically significant elevation is observed between six months and two years and a subsequent stabilisation of values between two and five years, with a cobalt mean at six months (1.17±0.8) significantly lower than at two (2.63±1.76) and five years (2.84±2.1), p=.001.

CONCLUSION

Elevated serum cobalt levels have been observed in patients who underwent modular neck stem implantation. The results obtained in this study have limited the use of stems with a modular neck in our clinical practice.

摘要

引言与目的

模块化颈干型假体被引入,其理论优势在于能更精确地恢复髋关节解剖结构。然而,第二个连接部位的存在与腐蚀增加及金属碎屑释放有关。我们研究的目的是量化血清中铬和钴的含量,并分析其在五年内的时间变化情况。

材料与方法

我们前瞻性地纳入了61例行初次全髋关节置换术并植入H MAX-M® 假体柄(Limacorporate,意大利圣丹尼尔)的患者。在术后6个月、2年和5年时测定血清铬和钴含量。

结果

我们的研究系列显示铬水平呈逐渐升高趋势,6个月时铬值(0.35±0.18)与5年时(0.52±0.36)有显著差异,p = 0.01。关于钴,在6个月至2年之间观察到有统计学意义的升高,随后在2年至5年之间值趋于稳定,6个月时钴的平均值(1.17±0.8)显著低于2年时(2.63±1.76)和5年时(2.84±2.1),p = 0.001。

结论

在接受模块化颈干型假体植入的患者中观察到血清钴水平升高。本研究所得结果限制了我们临床实践中模块化颈干型假体柄的使用。

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