Department of Neurology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA.
Department of Physical Medicine and Rehabilitation, University of Pennsylvania, 1800 Lombard Street, Philadelphia, PA 19146, USA.
Phys Med Rehabil Clin N Am. 2024 Feb;35(1):51-64. doi: 10.1016/j.pmr.2023.06.017. Epub 2023 Jul 7.
There is a clinical need for more accurate diagnosis and prognostication in patients with disorders of consciousness (DoC). There are several neuroimaging modalities that enable detailed, quantitative assessment of structural and functional brain injury, with demonstrated diagnostic and prognostic value. Additionally, longitudinal neuroimaging studies have hinted at quantifiable structural and functional neuroimaging biomarkers of recovery, with potential implications for the management of DoC.
对于意识障碍(DOC)患者,临床需要更准确的诊断和预后判断。有几种神经影像学方法可以对结构和功能脑损伤进行详细、定量的评估,具有明确的诊断和预后价值。此外,纵向神经影像学研究提示了可量化的结构和功能神经影像学恢复生物标志物,这可能对意识障碍的治疗管理有影响。