Department of Otorhinolaryngology, Pengzhou Hospital of Traditional Chinese Medicine, Chengdu, Sichuan, China.
College of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Auris Nasus Larynx. 2024 Apr;51(2):365-370. doi: 10.1016/j.anl.2023.11.006. Epub 2023 Nov 22.
While numerous observational studies have indicated an association between lipids and Sudden Sensorineural Hearing Loss (SSNHL), it remains uncertain whether dyslipidemia serves as a causal risk factor for SSNHL. Our objective is to elucidate the potential causal relationship between lipid levels and SSNHL through Mendelian randomization analysis.
The primary and secondary lipid data used in this study were sourced from the UK Biobank (UKBB) and the Global Lipid Genetics Consortium results (GLGC), respectively. These datasets were obtained from large, publicly available genome-wide association studies (GWAS). The outcome data for sudden sensorineural hearing loss (SSNHL) were acquired from the Finnegan Biobank, consisting of 1491 cases and 196,592 controls. Subsequently, both single-variable Mendelian randomization (SVMR) and multivariate Mendelian randomization (MVMR) methods were employed to evaluate the causal relationship between lipids and the occurrence of SSNHL.
Among the primary lipid data, SVMR analysis showed a significant correlation between high density lipoprotein cholesterol (HDL-C) (OR: 0.822, 95 %CI: 0.694-0.974, p = 0.023) and SSNHL, and triglycerides (TG) (OR: 0.997, 95 %CI: 0.836-1.188, p = 0.975), low density lipoprotein cholesterol (LDL-C) (OR: 1.067, 95 %CI: 0.861-1.322, p = 0.552) did not correlate with SSNHL. In the secondary lipid data, SVMR analysis showed that HDL-C (OR: 0.987, 95 %CI: 0.805-1.210, p = 0.903), TG (OR: 0.991, 95 %CI: 0.787-1.246, p = 0.937) and LDL-C (OR: 1.092, 95 % CI: 0.926-1.287, p = 0.294) did not correlate with SSNHL. MVMR analysis of the primary lipid data showed that HDL-cholesterol (OR: 0.755, 95 % CI: 0.596-0.956, p = 0.019) was significantly associated with SSNHL, while TG (OR: 0.808, 95 %CI: 0.611-1.068, p = 0.134) and LDL-C (OR: 1.146, 95 %CI: 0.869-1.511, p = 0.333) did not correlate with SSNHL, consistent with the results of SVMR. Inverse MR results showed that SSNHL did not correlate with TG (OR: 0.999, 95 %CI: 0.997-1.001, p = 0.835), HDL-C (OR: 1.001, 95 %CI: 0.998-1.003), LDL-C (OR: 0.999, 95 %CI: 0.997-1.002, p = 0.863).
Mendelian randomization (MR) results suggest that decreased serum HDL-C levels are an independent risk factor for SSNHL. Monitoring and focusing on lipid levels may be of value in the prevention and treatment of SSNHL.
虽然大量观察性研究表明血脂与突发性聋（SSNHL）之间存在关联，但血脂异常是否是 SSNHL 的因果风险因素仍不确定。我们的目的是通过孟德尔随机化分析阐明血脂水平与 SSNHL 之间的潜在因果关系。
本研究主要和次要的脂质数据分别来自英国生物银行（UKBB）和全球脂质遗传学联盟（GLGC）的结果。这些数据集来自大型、公开的全基因组关联研究（GWAS）。突发性聋（SSNHL）的结果数据来自芬尼根生物库，包括 1491 例病例和 196592 例对照。随后，采用单变量孟德尔随机化（SVMR）和多变量孟德尔随机化（MVMR）方法评估脂质与 SSNHL 发生之间的因果关系。
在主要脂质数据中，SVMR 分析显示高密度脂蛋白胆固醇（HDL-C）（OR：0.822，95%CI：0.694-0.974，p=0.023）和甘油三酯（TG）（OR：0.997，95%CI：0.836-1.188，p=0.975）与 SSNHL 呈显著相关，而低密度脂蛋白胆固醇（LDL-C）（OR：1.067，95%CI：0.861-1.322，p=0.552）与 SSNHL 不相关。在次要脂质数据中，SVMR 分析显示 HDL-C（OR：0.987，95%CI：0.805-1.210，p=0.903）、TG（OR：0.991，95%CI：0.787-1.246，p=0.937）和 LDL-C（OR：1.092，95%CI：0.926-1.287，p=0.294）与 SSNHL 不相关。主要脂质数据的 MVMR 分析显示 HDL-胆固醇（OR：0.755，95%CI：0.596-0.956，p=0.019）与 SSNHL 显著相关，而 TG（OR：0.808，95%CI：0.611-1.068，p=0.134）和 LDL-C（OR：1.146，95%CI：0.869-1.511，p=0.333）与 SSNHL 不相关，与 SVMR 结果一致。反向 MR 结果表明，TG（OR：0.999，95%CI：0.997-1.001，p=0.835）、HDL-C（OR：1.001，95%CI：0.998-1.003）和 LDL-C（OR：0.999，95%CI：0.997-1.002，p=0.863）与 SSNHL 不相关。
孟德尔随机化（MR）结果表明，血清 HDL-C 水平降低是 SSNHL 的一个独立危险因素。监测和关注血脂水平可能对 SSNHL 的预防和治疗具有重要价值。
