MAGI'S LAB, Rovereto (TN), Italy.
Department of Pharmaceutical Sciences, University of Perugia, Italy.
Clin Ter. 2023 Nov-Dec;174(Suppl 2(6)):21-28. doi: 10.7417/CT.2023.2468.
Cancer, a potentially fatal condition, is one of the leading causes of death worldwide. Among males aged 20 to 35, the most common cancer in healthy individuals is testicular cancer, accounting for 1% to 2% of all cancers in men.
Throughout this review, we have employed a targeted research approach, carefully handpicking the most representative and relevant articles on the subject. Our methodology involved a systematic review of the scientific literature to ensure a comprehensive and accurate overview of the available sources.
The onset and spread of testicular cancer are significantly influenced by genetic changes, including mutations in oncogenes, tu-mor suppressor genes, and DNA repair genes. As a result of identifying these specific genetic mutations in cancers, targeted medications have been developed to disrupt the signaling pathways affected by these genetic changes. To improve the diagnosis and treatment of this disease, it is crucial to understand its natural and clinical histories.
In order to comprehend cancer better and to discover new biomarkers and therapeutic targets, oncologists are increasingly employing omics methods, such as genomics, transcriptomics, proteomics, and metabolomics. Targeted medications that focus on specific genetic pathways and mutations hold promise for advancing the diagnosis and management of this disease.
癌症是一种潜在致命的疾病，是全球主要死因之一。在 20 至 35 岁的男性中，健康个体中最常见的癌症是睾丸癌，占男性所有癌症的 1%至 2%。
在本次综述中，我们采用了有针对性的研究方法，精心挑选了有关该主题最具代表性和最相关的文章。我们的方法包括对科学文献进行系统综述，以确保全面准确地概述现有资源。
睾丸癌的发生和扩散受遗传变化的显著影响，包括癌基因、肿瘤抑制基因和 DNA 修复基因的突变。由于在癌症中发现了这些特定的遗传突变，已经开发出靶向药物来破坏受这些遗传变化影响的信号通路。为了改善对这种疾病的诊断和治疗，了解其自然和临床病史至关重要。
为了更好地理解癌症，并发现新的生物标志物和治疗靶点，肿瘤学家越来越多地采用组学方法，如基因组学、转录组学、蛋白质组学和代谢组学。针对特定遗传途径和突变的靶向药物有望推进对这种疾病的诊断和管理。
