Department of Neonatology, Tianjin Central Hospital of Obstetrics and Gynecology, Tianjin, China.
Tianjin Key Laboratory of Human Development and Reproductive Regulation, Tianjin, China.
Histol Histopathol. 2024 May;39(5):557-564. doi: 10.14670/HH-18-675. Epub 2023 Nov 15.
With the continuous advancement of neonatal intensive care technology, the survival rate of preterm infants is gradually increasing. However, this improvement in survival is accompanied by long-term prognostic implications in various systems. In the field of renal diseases, current epidemiological data indicate that preterm birth is a significant risk factor for the development of long-term chronic kidney disease (CKD). This not only imposes an economic burden on patients families but also severely impacts their quality of life. Understanding the underlying mechanisms involved in this process could offer potential strategies for early prevention and management of CKD. Although the nephron number hypothesis is currently widely accepted as a mechanism, there has been limited exploration regarding podocytes - one of the most important structures within nephrons - in relation to long-term CKD associated with preterm birth. Therefore, this review aims to summarize current knowledge on how prematurity influences CKD development overall, while specifically focusing on our current understanding of podocytes in relation to prematurity.
随着新生儿重症监护技术的不断进步，早产儿的存活率逐渐提高。然而，这种生存率的提高伴随着各系统长期预后的影响。在肾脏疾病领域，目前的流行病学数据表明，早产是导致长期慢性肾脏病（CKD）的重要危险因素。这不仅给患者家庭带来了经济负担，也严重影响了他们的生活质量。了解这一过程中的潜在机制可能为 CKD 的早期预防和管理提供潜在策略。尽管目前广泛接受的是肾单位数量假说，但对于足细胞——肾单位中最重要的结构之一——与早产相关的长期 CKD 的关系，研究还很有限。因此，本综述旨在总结目前关于早产如何影响 CKD 发展的知识，同时特别关注我们对足细胞与早产相关的认识。
