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微生物特写:- 神出鬼没。

Microbe Profile: - stealthy as it goes.

机构信息

CIRAD, UMR ASTRE, Centre for Research and surveillance on Vector-borne diseases in the Caribbean, WOAH Reference Laboratory for Heartwater, F- 97170 Petit-Bourg, Guadeloupe, France.

ASTRE, CIRAD, INRAE, Univ Montpellier, Montpellier, France.

出版信息

Microbiology (Reading). 2023 Nov;169(11). doi: 10.1099/mic.0.001415.

Abstract

is an obligate intracellular pathogenic bacterium that causes heartwater, a fatal disease of ruminants in tropical areas. Some human cases have also been reported. This globally important pathogen is primarily transmitted by ticks of the genus and threatens American mainland. replicates within eukaryotic mammal or tick cell is a membrane-bound vacuole, where it undergoes a biphasic developmental growth cycle and differentiates from noninfectious replicative form into infectious elementary bodies. The ability of to hijack host cellular processes and avoid innate immunity is a fundamental, but not yet fully understood, virulence trait of this stealth pathogen in the genomic era.

摘要

是一种专性细胞内寄生细菌,可引起热带地区反刍动物的致命疾病——心水病。也有一些人类病例的报告。这种在全球范围内具有重要意义的病原体主要通过 和 属的蜱传播,威胁着美国大陆。在真核哺乳动物或蜱细胞内复制的是一个有膜的空泡,在那里它经历一个两相发育生长周期,并从非感染性复制形式分化为感染性的原始体。在基因组时代, 劫持宿主细胞过程并逃避先天免疫的能力是这种隐形病原体的一个基本但尚未完全了解的毒力特征。

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