Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Skłodowska-Curie National Research Institute of Oncology in Warsaw, Warsaw, Poland.
Faculty of Medicine, Medical University of Warsaw, Warsaw, Poland.
J Cancer Res Clin Oncol. 2023 Dec;149(20):18271-18281. doi: 10.1007/s00432-023-05451-1. Epub 2023 Nov 23.
The usual site for distant metastases of sarcoma is lungs, while brain metastasis (BM) occurs much less frequently and usually late in the disease progression. Despite the advancement in cancer treatment, the outcome for patients with brain metastasis is poor, and their lifespan is short. The frequency of BM in sarcoma seems to be affected by the location and histology of the primary tumour. Sarcoma subtypes with a high propensity for brain metastasis are ASPS, leiomyosarcoma and osteosarcoma. There are no clear guidelines for the treatment of sarcoma brain metastasis. However, therapeutic options include surgery, radiotherapy and chemotherapy, and are often combined. Targeted therapies are a promising treatment option for sarcoma but require investigation in patients with BM. The following review presents the data on sarcoma brain metastasis incidence, treatment and prognosis.
肉瘤远处转移的常见部位是肺部，而脑转移（BM）的发生则要少见得多，且通常发生在疾病进展的晚期。尽管癌症治疗取得了进展，但脑转移患者的预后仍然较差，生存期较短。BM 在肉瘤中的发生频率似乎受原发肿瘤的位置和组织学的影响。易发生脑转移的肉瘤亚型包括 ASPS、平滑肌肉瘤和骨肉瘤。目前尚无针对肉瘤脑转移的治疗指南。然而，治疗选择包括手术、放疗和化疗，且通常联合应用。靶向治疗是肉瘤治疗的一种有前途的选择，但需要在 BM 患者中进行研究。以下综述介绍了肉瘤脑转移的发生率、治疗和预后数据。
