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[阿米巴肝脓肿治疗中的各种考量]

[Various considerations in the treatment of amebic liver abscess].

作者信息

Esquivel López A, González Espínola G, García Garduño J R, Guarner Dalias V

出版信息

Rev Gastroenterol Mex. 1979 Apr-Jun;44(2):51-6.

PMID:379955
Abstract

From 1974 to 1976 Acute Amoebic Hepatic Abscess treatment was viewed retrospectively with a random double blind prospective study administering metronidazol emetine, or a combination of both to three groups of 20 patients per group. The retrospective study of 1974 underlines the then predominant tendency toward a surgical management with a higher mortality (p less than 0.002). In 1976 medical treatment patients increased with a corresponding diminution of mortality (p less than 0.001). The prospective study showed no statistically significant response difference to the pharmacologic treatment variations. Here only 1.6% of patients underwent surgery and 1/3 of them received puncture drainage due to medical treatment failure. We conclude that non complicated acute amoebic liver abscess treatment should be medical, preferably with only one antiamoebic drug.

摘要

1974年至1976年期间,我们通过一项随机双盲前瞻性研究对急性阿米巴肝脓肿的治疗进行了回顾性分析,该研究将甲硝唑、吐根碱或两者联合用药分别给予三组患者,每组20例。1974年的回顾性研究强调了当时以手术治疗为主的倾向,死亡率较高(p<0.002)。1976年,接受药物治疗的患者增多,死亡率相应降低(p<0.001)。前瞻性研究表明,药物治疗方案的变化在统计学上没有显著的反应差异。在此研究中,仅1.6%的患者接受了手术,其中1/3因药物治疗失败而接受了穿刺引流。我们得出结论,非复杂性急性阿米巴肝脓肿的治疗应以药物治疗为主,最好仅使用一种抗阿米巴药物。

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