奎尼丁诱发的反应性淋巴结病。

Quinidine-induced reactive lymphadenopathy.

作者信息

Gay R G, Fielder K L, Grogan T M

出版信息

Am J Med. 1987 Jan;82(1):143-5. doi: 10.1016/0002-9343(87)90392-5.

Abstract

This report describes a patient who presented with extensive inguinal lymphadenopathy while taking quinidine for the treatment of arrhythmias. An excisional lymph node biopsy specimen demonstrated atypical, reactive, follicular hyperplasia. Immunologic assessment utilizing 20 monoclonal antibodies indicated a reactive process with follicles shown to be polyclonal B cell. The patient's adenopathy resolved within one month of discontinuation of quinidine and he remains well 15 months later. The histologic and immunologic findings as well as the clinical response are typical for a drug-induced reactive lymphadenopathy.

摘要

本报告描述了一名在服用奎尼丁治疗心律失常时出现广泛腹股沟淋巴结病的患者。切除的淋巴结活检标本显示为非典型、反应性滤泡增生。利用20种单克隆抗体进行的免疫评估表明这是一个反应性过程，滤泡显示为多克隆B细胞。患者的淋巴结病在停用奎尼丁后一个月内消退，15个月后仍状况良好。组织学和免疫学发现以及临床反应是药物性反应性淋巴结病的典型表现。