Institute of Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital of Essen, Hufelandstraße 55, 45147, Essen, Germany.
BMC Public Health. 2023 Nov 24;23(1):2324. doi: 10.1186/s12889-023-17254-7.
In former studies, parity was associated with adverse cardiovascular outcomes in parents. This study aims to extend the limited existing data regarding the association between the number of children and heart disease and/or stroke in a large longitudinal study in different European countries in both men and women.
For 42 075 subjects (18 080 men, 23 995 women; median age 58 years (interquartile range: 53 to 65)) from 19 European countries and Israel in the Survey of Health, Ageing and Retirement in Europe (SHARE), odds ratios (OR) for the association between number of children and incident self-reported heart disease and/or stroke (HDS) were estimated using logistic regression analyses. Persons with one or two children were used as reference. The final model was adjusted for baseline age, sex, education, region, and marital status. All analyses were stratified by sex.
Women with seven or more children had the highest OR for the association between the number of children and incident HDS (OR = 2.12 [95% CI: 1.51 to 2.98]), while men with six children showed the highest OR (OR = 1.62 [1.13 to 2.33]). Stratified by education, across all education levels, men and women with five or more children had the highest ORs for this association. The highest OR was observed in both women and men in the group with primary education (OR = 1.66 [1.29 to 2.15] and OR = 1.60 [1.19 to 2.14], respectively). Stratified by region, both men and women with five or more children showed the highest ORs in Southern Europe (OR = 2.07 [1.52 to 2.82] and OR = 1.75 [1.25 to 2.44], respectively).
In this long-term follow-up study in various countries in Europe and Israel we found a positive association between number of children and incident HDS. This association was more pronounced in lower educated subjects and showed regional variations.
在之前的研究中，生育子女的数量与父母的心血管不良结局相关。本研究旨在通过在欧洲不同国家的一项大型纵向研究，扩展现有关于子女数量与男性和女性心脏病和/或中风之间关联的有限数据。
在欧洲 19 个国家和以色列的欧洲健康、老龄化和退休研究（SHARE）中，对 42075 名受试者（18080 名男性，23995 名女性；中位年龄 58 岁[四分位距：53 至 65]）进行了分析。使用逻辑回归分析估计了子女数量与报告的新发心脏病和/或中风（HDS）事件之间的关联的比值比（OR）。将有一个或两个孩子的人作为参照。最终模型调整了基线年龄、性别、教育程度、地区和婚姻状况。所有分析均按性别分层。
生育 7 个或更多孩子的女性发生 HDS 的 OR 最高（OR=2.12[95%CI：1.51 至 2.98]），而生育 6 个孩子的男性发生 HDS 的 OR 最高（OR=1.62[1.13 至 2.33]）。按教育程度分层，在所有教育水平中，生育 5 个或更多孩子的男性和女性发生该关联的 OR 最高。在女性和男性中，该关联的最高 OR 均出现在接受初等教育的人群中（OR=1.66[1.29 至 2.15]和 OR=1.60[1.19 至 2.14]）。按地区分层，在南部欧洲，生育 5 个或更多孩子的男性和女性发生 HDS 的 OR 最高（OR=2.07[1.52 至 2.82]和 OR=1.75[1.25 至 2.44]）。
在这项欧洲多个国家和以色列的长期随访研究中，我们发现子女数量与 HDS 事件之间存在正相关。这种关联在受教育程度较低的人群中更为明显，并存在地域差异。
