University of Hawai'i at Mānoa, Honolulu, USA.
J Aging Health. 2020 Aug-Sep;32(7-8):517-529. doi: 10.1177/0898264319831512. Epub 2019 Mar 10.
To examine the association of number of children birthed/fathered with incident heart disease, accounting for socioeconomic and lifestyle characteristics. We analyzed data from 24,923 adults 50 and older (55% women) in the Health and Retirement Study. Participants self-reported number of children and doctor-diagnosed incident heart disease. Cox proportional hazards models estimated heart disease risk. Compared to women with one to two children, those with five or more had increased risk of heart disease (hazard ratio [HR] = 1.13, 95% confidence interval [CI] = [1.03, 1.25]). Compared to men with one to two children, those with five or more had a marginally increased risk of heart disease (HR = 1.11, 95% CI = [0.99, 1.25]), but this association attenuated in models adjusting for socioeconomic and lifestyle variables. Compared to men with no children, those with five or more retained a borderline significant association in the fully adjusted model (HR = 1.15, 95% CI = [0.99, 1.35]). Social and lifestyle pathways appear to link parenthood to cardiovascular health.
为了研究生育/父亲的子女数量与新发心脏病之间的关联，我们考虑了社会经济和生活方式特征。我们分析了来自健康与退休研究的 24923 名 50 岁及以上成年人（55%为女性）的数据。参与者报告了他们生育的子女数量和医生诊断的新发心脏病。Cox 比例风险模型估计了心脏病的风险。与生育一到两个孩子的女性相比，生育五个或更多孩子的女性患心脏病的风险增加（风险比[HR] = 1.13，95%置信区间[CI] = [1.03，1.25]）。与生育一到两个孩子的男性相比，生育五个或更多孩子的男性患心脏病的风险略有增加（HR = 1.11，95% CI = [0.99，1.25]），但在调整社会经济和生活方式变量的模型中，这种关联减弱。与没有孩子的男性相比，在完全调整的模型中，生育五个或更多孩子的男性与心脏病仍存在边缘显著关联（HR = 1.15，95% CI = [0.99，1.35]）。社会和生活方式途径似乎将为人父母与心血管健康联系起来。
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