Department of Hematology-Oncology, Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing, China.
J Cell Mol Med. 2023 Dec;27(23):3939-3947. doi: 10.1111/jcmm.17995. Epub 2023 Nov 23.
Central nervous system (CNS) involvement in Hodgkins lymphoma (HL) is extremely rare. There are only two reported case series of intracranial involvement of HL. CNS HL can be presented at any point in the course of HL, most mimicking with a prominent neurological symptom. This challenges the diagnosis of CNS involvement and stroke. Here, we report four cases of patients having refractory HL with CNS involvement to garner attention among neurologists for this rare disease presents with stroke symptoms and reviews its disease characteristics, prognosis, and treatment.
中枢神经系统(CNS)受累于霍奇金淋巴瘤(HL)极为罕见。仅有两例关于 HL 颅内受累的病例系列报道。CNS HL 可在 HL 病程的任何阶段出现,多数表现为突出的神经症状。这就对 CNS 受累和中风的诊断提出了挑战。在此,我们报告了 4 例患有难治性 HL 合并 CNS 受累的患者,以引起神经科医生对这种以中风症状为表现的罕见疾病的关注,并回顾其疾病特征、预后和治疗。