School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
Exp Dermatol. 2024 Jan;33(1):e14984. doi: 10.1111/exd.14984. Epub 2023 Nov 23.
Many clinical studies have demonstrated a correlation between psoriasis vulgaris and dementia, yet this correlation remains controversial. Our study employed the Mendelian randomization (MR) method to investigate the causal relationship between psoriasis vulgaris and dementia. Data were obtained from the summary statistics of the genome-wide association studies from IEU-OpenGWAS project database. In univariate Mendelian randomization (UVMR) analysis, psoriasis vulgaris was used as exposure. Alzheimer disease (AD), vascular dementia (VaD), dementia with Lewy bodies (DLB), Parkinson's disease with dementia (PDD) and frontotemporal dementia (FTD) served as the outcomes. In multivariate Mendelian randomization (MVMR) analysis, VaD served as the outcome. The first MVMR analysis used psoriasis vulgaris, mean platelet volume (MPV), platelet distribution width (PDW) and platelet count (PLT) as exposures. The second MVMR analysis used psoriasis vulgaris, vitamin D level and 25 hydroxyvitamin D level as exposures. The main analysis employed the inverse variance weighted method, and the outcomes were evaluated by odds ratio (OR) and 95% confidence interval (95% CI). In UVMR analysis, the results depicted that psoriasis vulgaris was associated with VaD (OR: 0.903, 95% CI: 0.818-0.996, p = 0.041). The results revealed insignificant associations between psoriasis vulgaris and other dementia types. After adjusting the effects of MPV, PDW and PLT in MVMR analysis, the association between psoriasis vulgaris and VaD was no longer significant (p = 0.164). Similarly, after adjusting the effects of vitamin D level and 25 hydroxyvitamin D level in MVMR analysis, the association between psoriasis vulgaris and VaD was also no longer significant (p = 0.533). Our study suggests that psoriasis vulgaris may potentially decrease VaD incidence. However, the causal association between psoriasis vulgaris and VaD may be impeded by platelet-related indices, vitamin D level and 25 hydroxyvitamin D level.
许多临床研究表明寻常型银屑病与痴呆之间存在相关性，但这种相关性仍存在争议。我们的研究采用孟德尔随机化（MR）方法来研究寻常型银屑病与痴呆之间的因果关系。数据来自 IEU-OpenGWAS 项目数据库的全基因组关联研究汇总统计数据。在单变量孟德尔随机化（UVMR）分析中，寻常型银屑病作为暴露因素。阿尔茨海默病（AD）、血管性痴呆（VaD）、路易体痴呆（DLB）、帕金森病伴痴呆（PDD）和额颞叶痴呆（FTD）作为结局。在多变量孟德尔随机化（MVMR）分析中，VaD 作为结局。第一次 MVMR 分析使用寻常型银屑病、平均血小板体积（MPV）、血小板分布宽度（PDW）和血小板计数（PLT）作为暴露因素。第二次 MVMR 分析使用寻常型银屑病、维生素 D 水平和 25 羟维生素 D 水平作为暴露因素。主要分析采用逆方差加权法，结果通过比值比（OR）和 95%置信区间（95%CI）进行评估。在 UVMR 分析中，结果表明寻常型银屑病与 VaD 相关（OR：0.903，95%CI：0.818-0.996，p=0.041）。结果显示寻常型银屑病与其他类型痴呆之间无显著关联。在 MVMR 分析中调整 MPV、PDW 和 PLT 的影响后，寻常型银屑病与 VaD 之间的关联不再显著（p=0.164）。同样，在 MVMR 分析中调整维生素 D 水平和 25 羟维生素 D 水平的影响后，寻常型银屑病与 VaD 之间的关联也不再显著（p=0.533）。我们的研究表明，寻常型银屑病可能会降低 VaD 的发生率。然而，寻常型银屑病与 VaD 之间的因果关系可能受到血小板相关指标、维生素 D 水平和 25 羟维生素 D 水平的阻碍。
