Institute of Acupuncture and Moxibustion, Shandong University of Traditional Chinese Medicine, Jinan, China; Innovation Research Institute of Chinese Medicine, Shandong University of Traditional Chinese Medicine, China.
Weifang Hospital of Traditional Chinese Medicine, Wei Fang, China.
J Affect Disord. 2024 Jun 15;355:167-174. doi: 10.1016/j.jad.2024.03.149. Epub 2024 Mar 27.
Major depressive disorder (MDD) and dementia psychiatric and neurological diseases that are clinically widespread, but whether there is a causal link between them is still unclear. In this study, bidirectional two-sample Mendelian randomization (MR) was used to investigate the potential causal relationship between MDD and dementia via a genome-wide association study (GWAS) database, containing samples from the European population.
We collected data on MDD and common clinical dementia subtypes from GWAS, including Alzheimer's disease (AD), frontotemporal dementia (FTD), dementia with Lewy bodies (DLB), Parkinson's disease with dementia (PDD), and vascular dementia (VaD). A series of bidirectional two-sample MR studies and correlation sensitivity analysis were carried out.
In the study of the effect of MDD on dementia subtypes, no causal relationship was found between MDD and dementia subtypes other than VaD, inverse variance weighted (IVW) method: odds ratio (OR), 2.131; 95 % confidence interval (CI), 1.249-3.639, P = 0.006; MDD-AD: OR, 1.000; 95 % CI, 0.999-1.001, P = 0.537; MDD-FTD: OR, 1.476; 95 % CI, 0.471-4.627, P = 0.505; MDD-PDD: OR, 0.592; 95 % CI, 0.204-1.718, P = 0.335; MR-Egger method: MDD-DLB: OR, 0.582; 95 % CI, 0.021-15.962, P = 0.751. In reverse MR analyses, no dementia subtype was found to be a risk factor for MDD.
The results of this study may not be generalizable to non-European populations.
MDD was identified as a potential risk factor for VaD, but no dementia subtype was found to be a risk factor for MDD. These results suggest a new avenue for the prevention of VaD.
重度抑郁症（MDD）和痴呆是两种常见的精神和神经疾病，但它们之间是否存在因果关系尚不清楚。在这项研究中，我们通过全基因组关联研究（GWAS）数据库，利用来自欧洲人群的样本，采用双向两样本 Mendelian 随机化（MR）方法来研究 MDD 和痴呆之间的潜在因果关系。
我们从 GWAS 中收集了 MDD 和常见的临床痴呆亚型的数据，包括阿尔茨海默病（AD）、额颞叶痴呆（FTD）、路易体痴呆（DLB）、帕金森病伴痴呆（PDD）和血管性痴呆（VaD）。进行了一系列双向两样本 MR 研究和相关性敏感分析。
在 MDD 对痴呆亚型影响的研究中，除 VaD 外，MDD 与其他痴呆亚型之间没有发现因果关系。反向方差加权（IVW）法：比值比（OR），2.131；95%置信区间（CI），1.249-3.639，P=0.006；MDD-AD：OR，1.000；95%CI，0.999-1.001，P=0.537；MDD-FTD：OR，1.476；95%CI，0.471-4.627，P=0.505；MDD-PDD：OR，0.592；95%CI，0.204-1.718，P=0.335；MR-Egger 法：MDD-DLB：OR，0.582；95%CI，0.021-15.962，P=0.751。在反向 MR 分析中，没有发现任何痴呆亚型是 MDD 的危险因素。
本研究结果可能不适用于非欧洲人群。
MDD 被确定为 VaD 的一个潜在危险因素，但没有发现任何痴呆亚型是 MDD 的危险因素。这些结果为 VaD 的预防提供了一个新的途径。
