Department of Chemistry, Visva-Bharati University, Santiniketan 731235, India.
Department of Natural Products, National Institute of Pharmaceutical Education and Research, Kolkata 700054, India.
ACS Appl Bio Mater. 2023 Dec 18;6(12):5442-5457. doi: 10.1021/acsabm.3c00675. Epub 2023 Nov 24.
Molecular self-assembly assisted self-healing supramolecular metallogels of azelaic acid with cobalt(II)-, nickel(II)-, and zinc(II)-based metal acetate salts were successfully fabricated. Individually, ,'-dimethylformamide and dimethyl sulfoxide were immobilized within these distinctly synthesized soft-scaffolds of metallogels to attain their semisolid viscoelastic nature. Rheological experiments such as amplitude sweep, frequency sweep, and thixotropic measurements were executed for these metallogels to ratify their gel features. The different extents of supramolecular interactions operating within these solvent-directed metallogels were clearly reflected in terms of their distinct morphological patterns as investigated through field emission scanning electron microscopy. Comparative infrared (IR) spectral properties of metallogels along with individual metal salts and azelaic acid were analyzed. These experimental data clearly depict the significant shifting of Fourier transform (FT)-IR peaks of xerogel samples of different metallogels from the gel-forming precursors. The networks present within the soft-scaffold are evidently illustrated by the electrospray ionization-mass experimental data. The temperature-dependent ionic conductivity studies with these solvent-directed versatile metallogel systems were investigated through impedance spectroscopy. The temperature-dependent impedance spectroscopic studies clearly demonstrate that the ion-transportation within the gel matrix depends not only on the types of cations but also on the dielectric properties of the immobilized solvents. The antipathogenic effect of these metallogel systems has also been explored by testing their effectiveness against human pathogenic Gram-negative bacteria (MTCC 109) and , and Gram-positive bacteria like (MTCC 1272). These gel soft-scaffolds show no significant cytotoxicity against both the human neuroblastoma cell line-SH-SY5Y and the human embryonic kidney cell line-HEK 293.
成功制备了以庚二酸为配体的钴（II）、镍（II）和锌（II）基金属醋酸盐的分子自组装辅助自修复超分子金属凝胶。单独地，二甲基甲酰胺和二甲基亚砜被固定在这些明显合成的金属凝胶软支架内，以获得它们的半固态粘弹性。对这些金属凝胶进行了诸如幅度扫描、频率扫描和触变测量等流变学实验，以证实它们的凝胶特性。通过场发射扫描电子显微镜研究，清楚地反映了这些溶剂导向的金属凝胶中存在的不同程度的超分子相互作用，反映在它们不同的形态模式上。分析了金属凝胶以及各个金属盐和庚二酸的比较红外（IR）光谱性质。这些实验数据清楚地表明，不同金属凝胶的干凝胶样品的傅里叶变换（FT）-IR 峰明显从凝胶形成前体发生了位移。通过电喷雾电离-质量实验数据清楚地说明了软支架内的网络。通过阻抗谱研究了这些溶剂导向的多功能金属凝胶系统的温度依赖性离子电导率。温度依赖性阻抗谱研究清楚地表明，凝胶基质内的离子输运不仅取决于阳离子的类型，而且还取决于固定溶剂的介电性质。还通过测试它们对人病原性革兰氏阴性菌（MTCC 109）和革兰氏阳性菌如（MTCC 1272）的有效性，研究了这些金属凝胶系统的抗病原体作用。这些凝胶软支架对人神经母细胞瘤细胞系-SH-SY5Y 和人胚肾细胞系-HEK 293 均无明显的细胞毒性。
