Song Xiaojun, Lin Ying, Zhang Yinfeng, Wang Zi, Li Xiaohan, Liu Jixiang, Jiang Wenwen, Chen Jianing, Wu Linxuan, Rong Junjie, Xu Kefeng, Wang Guodong
School of Marine Science and Engineering, Qingdao Agricultural University, Qingdao 266109, China.
College of Medicine, Qingdao University, Qingdao 266021, China.
Biology (Basel). 2023 Oct 25;12(11):1365. doi: 10.3390/biology12111365.
Tetrabromobisphenol A (TBBPA), a commonly utilized brominated flame retardant, is found in many types of abiotic and biotic matrices. TBBPA can increase oxidative stress, disrupt the endocrine system, cause neurodevelopmental disorders and activate peroxisome proliferator-activated receptors to modulate lipid deposits in aquatic animals. However, the toxic mechanism of TBBPA on the gut microbiota and intestinal health remains unclear. is an ideal model for studying the relationship between environmental contaminants and intestinal health due to its unique capacity for evisceration and quickly regenerated intestine. In the present study, we investigated the toxic mechanism of TBBPA on the gut microbiota and intestinal health in the regenerated intestine of . The results show that TBBPA exposure decreased the health of the regenerated intestine and the enzymatic activities, alpha diversity indices, and the relative abundance of the gut microbiota. Transcriptome analysis shows that TBBPA exposure affected lipid metabolism via the PPAR signaling pathway during the process of intestinal regeneration in , suggesting that TBBPA exposure can affect the composition and function of the gut microbiota and intestinal health in the regenerated intestine of . These results provide a basis for further research on the potential toxicity of TBBPA to the intestinal health in animals.
四溴双酚A（TBBPA）是一种常用的溴化阻燃剂，存在于多种非生物和生物基质中。TBBPA可增加氧化应激、扰乱内分泌系统、导致神经发育障碍并激活过氧化物酶体增殖物激活受体，从而调节水生动物体内的脂质沉积。然而，TBBPA对肠道微生物群和肠道健康的毒性机制仍不清楚。由于其具有独特的去内脏能力和快速再生肠道的能力，是研究环境污染物与肠道健康之间关系的理想模型。在本研究中，我们研究了TBBPA对[动物名称]再生肠道中肠道微生物群和肠道健康的毒性机制。结果表明，暴露于TBBPA会降低再生肠道的健康状况以及肠道微生物群的酶活性、α多样性指数和相对丰度。转录组分析表明，在[动物名称]肠道再生过程中，暴露于TBBPA会通过PPAR信号通路影响脂质代谢，这表明暴露于TBBPA会影响[动物名称]再生肠道中肠道微生物群的组成和功能以及肠道健康。这些结果为进一步研究TBBPA对动物肠道健康的潜在毒性提供了依据。
