Secunda S K, Swann A, Katz M M, Koslow S H, Croughan J, Chang S
Am J Psychiatry. 1987 Jan;144(1):96-8. doi: 10.1176/ajp.144.1.96.
In a study of 19 manic patients, the authors found that eight suffered from mixed mania, a condition in which depressive symptoms are found in the context of classic manic features. The presence of a mixed manic state predicted at least a slower and possibly a poor response to lithium therapy. The authors suggest that the delineation of a subgroup of mixed manic patients might help to identify potential lithium-resistant patients.
在一项针对19名躁狂患者的研究中，作者发现其中8人患有混合性躁狂症，即在典型躁狂特征背景下出现抑郁症状的一种病症。混合性躁狂状态的存在预示着至少对锂盐治疗的反应较慢，甚至可能疗效不佳。作者认为，划分出混合性躁狂患者亚组可能有助于识别潜在的锂盐抵抗患者。
