Xi Yan, Mao Yu, Yang Fan, Xi Peng, Zhu Wei, Song Yanli, Yan Wenwen, Liao Xudong, Zhou Lin
Department of General Practice, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China.
Department of Cardiology, Tongji Hospital, Tongji University, Shanghai 200065, China.
J Cardiovasc Dev Dis. 2023 Nov 15;10(11):461. doi: 10.3390/jcdd10110461.
Integrin β plays an important role in the pathogenesis of thrombosis and inflammation, and it may be a shared pathogenic mechanism between arterial and venous thromboses. With the goal of identifying new treatment targets for thrombotic diseases and specific diagnostic markers for venous thromboembolism (VTE), this prospective clinical study was performed to clarify the relationship between integrin and thrombosis. The levels of integrin β1-3, interleukin-6 (IL-6), and C-reactive protein were significantly higher in patients with acute myocardial infarction (AMI; = 44) and acute VTE ( = 43) compared to healthy controls ( = 33). The IL-6 and integrin β1-3 levels were also significantly higher in the AMI group compared to the VTE and control groups. Logistic regression analysis identified IL-6 and integrin β1-3 levels as independent risk factors for thrombotic disease. Based on the receiver-operating characteristic curve, Youden index, sensitivity, and specificity, the diagnostic accuracy value for VTE was greater than 0.8 when integrins β1, β2, and β3 were combined. Overall, these results suggest that integrin β levels can contribute to improving the diagnosis and treatment of arteriovenous thrombosis.
整合素β在血栓形成和炎症的发病机制中起重要作用，它可能是动脉血栓和静脉血栓之间共同的致病机制。为了确定血栓性疾病的新治疗靶点和静脉血栓栓塞症（VTE）的特异性诊断标志物，开展了这项前瞻性临床研究以阐明整合素与血栓形成之间的关系。与健康对照组（n = 33）相比，急性心肌梗死（AMI；n = 44）和急性VTE（n = 43）患者的整合素β1-3、白细胞介素-6（IL-6）和C反应蛋白水平显著更高。与VTE组和对照组相比，AMI组的IL-6和整合素β1-3水平也显著更高。逻辑回归分析确定IL-6和整合素β1-3水平为血栓性疾病的独立危险因素。基于受试者工作特征曲线、约登指数、敏感性和特异性，当整合素β1、β2和β3联合使用时，VTE的诊断准确性值大于0.8。总体而言，这些结果表明整合素β水平有助于改善动静脉血栓的诊断和治疗。
